AZD 2098 - CAS 566203-88-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C11H9Cl2N3O3S
Molecular Weight:
334.18
COA:
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Targets:
CCR
Description:
AZD 2098 is a potent and selective CCR4 receptor antagonist (pIC50 = 7.8) used for the treatment of allergic rhinitis. CCR4 is a molecule that can drive the immune cells toward the tumor cells.
Brife Description:
CCR4 receptor antagonist, allergic rhinitis
Purity:
99%
Synonyms:
AZD-2098; AZD 2098; AZD2098; 2,3-dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide
MSDS:
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Application:
the treatment of allergic rhinitis and asthma
InChIKey:
FLSMVCMSUNISFK-UHFFFAOYSA-N
InChI:
InChI=1S/C11H9Cl2N3O3S/c1-19-11-10(14-5-6-15-11)16-20(17,18)8-4-2-3-7(12)9(8)13/h2-6H,1H3,(H,14,16)
Canonical SMILES:
COC1=NC=CN=C1NS(=O)(=O)C2=C(C(=CC=C2)Cl)Cl
1.Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.
Kindon N;Andrews G;Baxter A;Cheshire D;Hemsley P;Johnson T;Liu YZ;McGinnity D;McHale M;Mete A;Reuberson J;Roberts B;Steele J;Teobald B;Unitt J;Vaughan D;Walters I;Stocks MJ ACS Med Chem Lett. 2017 Sep 1;8(9):981-986. doi: 10.1021/acsmedchemlett.7b00315. eCollection 2017 Sep 14.
N;-(5-Bromo-3-methoxypyrazin-2-yl)-5-chlorothiophene-2-sulfonamide ;1; was identified as a hit in a CCR4 receptor antagonist high-throughput screen (HTS) of a subset of the AstraZeneca compound bank. As a hit with a lead-like profile, it was an excellent starting point for a CCR4 receptor antagonist program and enabled the rapid progression through the Lead Identification and Lead Optimization phases resulting in the discovery of two bioavailable CCR4 receptor antagonist candidate drugs.
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Chemical Structure

CAS 566203-88-1 AZD 2098

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