|Description||AZD 2066 is a mGluR5 anatagonist. It displays discriminative effects in rats. It is brain penetrant and orally bioavailable. It is used to prevent and treat pain, psychiatric, neurological and other diseases.|
|Purity||≥98% by HPLC|
|Synonyms||AZD 2066; AZD2066; AZD-2066; 4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine|
JNJ-42153605 is a selective positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor (EC50= 17 Nm) with an acceptable pharmacokinetic prof...
Sodium salt of LY 379268. LY 379268 is a group II mGlu receptor agonist with EC50 values of 2.69 and 4.48 nM for hmGlu2 and hmGlu3. Some research shows that LY3...
A 841720 is a potent non-competitive mGlu1 receptor antagonist (IC50 = 10 nM) exhibiting 34-fold selectivity over mGluR5 and inactive to other mGluR receptors, ...
YM 298198 dihydrochloride
YM 298198 dihydrochloride is a selective mGluR-1 antagonist. In vivo, YM 298198 exhibits an antinociceptive effect in hyperalgesic mice.
ABP 688 is a high affinity human mGlu5 receptor antagonist (Ki = 1.7 nM) that inhibits the release of glutamate-induced calcium from L(tk-) cells expressing hum...
DL-AP3 has been found to be an inhibitor of mGluR as well as HPSP.
(±)-ADX 71743 has been found to be a negative allosteric modulator at mGlu7 and is brain penetrant.
L-Cysteinesulfinic acid is an agonist of mGlu1a and mGlu5a subtypes expressed in clonal RGT cell lines and an agonist of NMDA. It is used to probe conformationa...