|Description||AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition.|
|Appearance||Light yellow solid powder|
|Synonyms||AZD1208; AZD 1208.|
Tp3654 is an inhibitor of Pim-1 and Pim-3 that has the potential to treat prostate cancer, acute myeloid leukemia, multiple sclerosis and psoriasis.
PIM inhibitor 1 phosphate
PAK4-IN-1 is an inhibitor of Pim (IC50< 35 nM).
TCS PIM-1 1
TCS PIM-1 1(sc-204330) is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displaying good selectivity over Pim-2 and MEK1/MEK2...
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CX-6258 hydrochloride hydrate
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AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. AZD1208 inhibits the activities of PIM1, PIM2 and P...
This active molecular is a selective ATP-competitive inhibitor of Pan-PIM kinase. LGB-321 is active in PIM2 dependent cell lines that is quite different to othe...
LKB1/AAK1 dual inhibitor
LKB1/AAK1 dual inhibitor is an effective inhitor against multi-kinase especially Pim-1 kinase, which has been newly found to highly expressed in sorts of isolat...
(Z)-SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no a...
SGI-1776 is a small-molecule pan-Pim protein kinase inhibitor with potential antineoplastic activity. Pim kinase inhibitor SGI-1776 binds to and inhibits the ac...
GDC-0339, also called as SCHEMBL14801965, is a selective inhibitor of BaF3 PIM1 that has the potential for treatment of cancer. BaF3 PIM1: IC50= 43.6 nM; PIM1 L...
CX-6258 is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity.
This active molecular is a potent PIM 1, 2, and 3 kinase inhibitor under the development of Novartis. In vivo, PIM447 reduces the tumor burden and also prevente...
PIM-1 Inhibitor 2
PIM-1 Inhibitor 2, a pyrimidinyl-benzisoxazolo compound, is a potent Pim-1 inhibitor (Ki = 91 nM) that targets the ATP-binding kinase hinge region.
R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase. It inhibits Pim-1 phosphorylation of p27Kip1 and Bad, and induces cell cycle arrest (at G1) and...
SMI-4a, also called as TCS-PIM-1-4a, a thiazolidinedione compound, is a potent, selective ATP-competitive inhibitor against Pim protein kinase (IC50 = 24 nM aga...