|Description||AZD0837 is an oral direct thrombin inhibitor currently in clinical development for the prevention of stroke and systemic embolic events in patients with atrial fibrillation.|
|Synonyms||Atecegatran metoxil; 1-((2R)-(3-chloro-5- (difluoromethoxy)phenyl)hydroxyacetyl)-N-((4-(imino(methoxyamino)methyl)phenyl)methyl)-, (2S)-2-Azetidinecarboxamide; (S)-1-((R)-2-(3-chloro-5-(difluoromethoxy)phenyl)-2-hydroxyacetyl)-N-(4-(N-methoxycarbamimidoyl)benzyl)azetidine-2-carboxamide;|
|Solubility||Soluble in DMSO|
|Storage||Store at -20 °C|
|Application||Potassium channel antagonist|
|Quality Standard||Enterprise standard|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.|
BeKm 1 is a potent and selective KV11.1 (hERG) channel blocker.
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GW 542573X is an activator of small-conductance Ca2+-activated K+ channels (KCa2) with selectivity for KCa2.1 (EC50 = 8.2 μM in HEK293 cells expressing hKCa2.1)...
Diazoxide is a benzothiadiazine derivative which acts as a potassium channel activator.
NS 8593 hydrochloride
NS8593 HCl is a selective KCa2 channel negative modulator.
UK 78282 hydrochloride
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UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker that reduces sAHP in hippocampal slice preparations. UCL 2077 exhibits no effect on Ca2+ curren...
RPR-260243 is a selective activator of the Human Ether-ago-go-Related Gene (hERG) (IC50 = 58 nM).
PK-THPP is a potent antagonist of tandem pore potassium channel subunit TASK-3 (KCNK9, K2P9.1) with an IC50 value of 35 nM for TASK-3 compared to 303 nM for TAS...
Vonoprazan is a first-in-class potassium-competitive acid blocker (P-CAB) reversibly inhibiting gastric H+, K+-ATPase. It can be used for the treatment of gastr...
A Kv11.1 (hERG) channel blocker. Azimilide is a class III antiarrhythmic drug and it can be used to control abnormal heart rhythms.
Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.
TAK-438 is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretio...
Way 123398 is a class III antiarrhythmic agent. It is a Potassium channel antagonist originated by Wyeth. No preclinical development for Arrhythmias in USA was ...
NS 3623 is a KV11.1 (hERG) and KV4.3 channel activator. It can activate the IKr and Ito currents and display antiarrhythmic activity.
ZM 226600 is a potent Kir6 (KATP) channel opener (EC50 = 0.5 μM) devoid of antiandrogen properties.
Vernakalant hydrochloride, also known as RSD1235, is a novel, relatively atrial-selective antiarrhythmic drug which can terminate acute atrial fibrillation (AF)...
(-)-[3R,4S]-Chromanol 293B is one of the chromanols, which inhibits cAMP-mediated Cl- secretion in colon crypts by a blockade of a cAMP-activated K+ conductance...
Phe-Met-Arg-Phe, amide, also called as FMRF-NH2, belongs to Molluscan Cardioexcitatory Neuropeptide and dose dependently (ED50=23 nM) activates a K+current in t...
BL 1249 is a putative potassium channel activator and acts as a K2P2.1 (TREK-1) channel opener. It exhibits selectivity for bladder over vascular tissue in vitr...