|Description||AZD0837 is an oral direct thrombin inhibitor currently in clinical development for the prevention of stroke and systemic embolic events in patients with atrial fibrillation.|
|Synonyms||Atecegatran metoxil; 1-((2R)-(3-chloro-5- (difluoromethoxy)phenyl)hydroxyacetyl)-N-((4-(imino(methoxyamino)methyl)phenyl)methyl)-, (2S)-2-Azetidinecarboxamide; (S)-1-((R)-2-(3-chloro-5-(difluoromethoxy)phenyl)-2-hydroxyacetyl)-N-(4-(N-methoxycarbamimidoyl)benzyl)azetidine-2-carboxamide;|
|Solubility||Soluble in DMSO|
|Storage||Store at -20 °C|
|Application||Potassium channel antagonist|
|Quality Standard||Enterprise standard|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.|
Mitiglinide calcium hydrate
Mitiglinide calcium hydrate, a derivative of benzylsuccinic acid, is a highly selective KATP channel antagonist.
NS6180 is a potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). NS6180 prevents T...
Vonoprazan is a first-in-class potassium-competitive acid blocker (P-CAB) reversibly inhibiting gastric H+, K+-ATPase. It can be used for the treatment of gastr...
Way 123398 is a class III antiarrhythmic agent. It is a Potassium channel antagonist originated by Wyeth. No preclinical development for Arrhythmias in USA was ...
Doxapram is a respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate. Doxapram stimulates chem...
Naminidil is an ATP-Sensitive Potassium Channel Vasodilator used for the treatment of Alopecia.
(±)-BMS 204352 is a potassium channel opener that can be used in the study of buspirone metabolites for treating movement disorders.
AZD0837 is an oral direct thrombin inhibitor currently in clinical development for the prevention of stroke and systemic embolic events in patients with atrial ...
Minoxidil is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth.
ML277, a sulfonylpiperidine compound, has been found to be a KCNQ1 K+ channel activator and could be used in the study of the activity of K+ channel in human ca...
ICA-069673 is an orally active, potent and selective KCNQ2/Q3 potassium channel activator (IC50= 0.69 μM) with 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV...
MK 499, also know as L706000, has been found to be a potassium channel antagonist that has been once studied the activity in the treatment of arrhythmias. The P...
Celikalim is s ATP-sensitive potassium channel agonist originated by Wyeth. It increases K+ outward flux in dog and human airway smooth muscle. But clinical tri...
Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.
Diazoxide is a benzothiadiazine derivative which acts as a potassium channel activator.
S 9947 is a Kv1.5 or IKur channel blocker exhibiting a dual inhibitory effect against cloned (Kv1.5) and native (IKur) cardiac potassium current.
BMS 180448 is a prototype mitochondrial ATP-sensitive K+ channel stimulant. The cardioprotective effects of BMS-180448 against I/R heart injury may result from ...
TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM).
Glyburide (Glibenclamide) is an anti-diabetic compound in a class of medications known as sulfonylureas, closely related to sulfa agents.
Tifenazoxide is a potent selective KATP channels opener with preference for Kir6.2/SUR1. Studies show that it inhibits glucose stimulated insulin release in vit...