Avridine - CAS 35607-20-6
Catalog number: 35607-20-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Avridine is a potent synthetic non-immunogenic adjuvant that used to induce arthritis in Lewis (LEW) and DA rats.
Publictions citing BOC Sciences Products
  • >> More
Off-white solid
CP 20961; N,N-Dioctadecyl-N',N'-bis(2-hydroxyethyl)-1,3-diaminopropane;
Soluble in DMSO
Store at -20 °C
A potent synthetic non-immunogenic adjuvant that can induce arthritis in most rat strains; immunomodulator and interferon-inducing.
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Melting Point:
39-40 °C
Canonical SMILES:
1.Effect of bacillus of Calmette-Guérin, avridine and Propionibacterium acnes as immunomodulators on rabies in mice.
Megid J1, Peraçoli MT, Curi PR, Zanetti CR, Cabrera WH, Vassao R, Ito FH. Rev Inst Med Trop Sao Paulo. 1999 Mar-Apr;41(2):107-14.
The cellular and humoral immune responses of mice inoculated with rabies virus and treated with the Bacillus of Calmette-Guérin, Avridine and Propionibacterium acnes were evaluated in this paper. There was a higher percentage of surviving mice in groups submitted to P. acnes treatment. Lower levels of interferon-gamma (IFN-gamma) were found in infected mice. The intra-pad inoculation test (IPI) was not effective to detect cellular immune response, contrary to the results found in MIF reaction. The survival of mice did not present correlation with the levels of antirabies serum neutralizing (SN) antibodies titers, IFN-gamma concentration and MIF response.
2.Adjuvant effects of sulfolipo-cyclodextrin in a squalane-in-water and water-in-mineral oil emulsions for BHV-1 vaccines in cattle.
Romera SA1, Hilgers LA, Puntel M, Zamorano PI, Alcon VL, Dus Santos MJ, Blanco Viera J, Borca MV, Sadir AM. Vaccine. 2000 Aug 15;19(1):132-41.
The antibody and cell mediated immune responses induced by BHV-1 were analysed in cattle after vaccination and challenge exposure to the virulent strain LA of BHV-1. Animals were vaccinated intramuscularly (IM) with inactivated virus vaccines against BHV-1 containing either a water in mineral oil adjuvant (W/O), a water in mineral oil adjuvant plus Avridine (W/O+Avridine) or sulfolipo-cyclodextrin in squalane in-water emulsion (SL-CD/S/W). No significant differences were registered in the antibody response induced by the three evaluated vaccines. However, the BHV-1 specific cell-mediated immunite response was stronger and appeared earlier when SL-CD/S/W was included in the formulation. The efficacy of the vaccines was also evaluated after intranasal challenge of the calves with a virulent BHV-1 LA strain. Animals vaccinated with SL-CD/S/W had reduced virus excretion and clinical symptoms compared with the mock-vaccinated animals. Comparison of levels of BHV-1 specific IgG2 and IgG1 with virus shedding revealed that, regardless of the adjuvant administered, animals showing BHV-1 specific IgG2/IgG1 ratios higher than 1 were those with a significant lower number of individuals shedding virus.
3.Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis.
Holmdahl R1, Lorentzen JC, Lu S, Olofsson P, Wester L, Holmberg J, Pettersson U. Immunol Rev. 2001 Dec;184:184-202.
Rat models are useful for studies of the pathogenesis of rheumatoid arthritis (RA) since rats are extraordinarily sensitive to induction of arthritis with adjuvants. Injection of not only the classical complete Freund's adjuvant but also mineral oil without mycobacteria and pure adjuvants such as pristane and squalene, induce severe arthritis in many rat strains. Models like pristane-induced arthritis in rats are optimal models for RA since they fulfill the RA criteria including a chronic relapsing disease course. Arthritogenic adjuvants like pristane, avridine, squalene and mineral oil are not immunogenic since they do not contain major histocompatibility complex (MHC) binding peptides. Nevertheless, the diseases are MHC-associated and dependent on the activation of alphabetaTCR (T-cell receptor)-expressing T cells. However, it has not been possible to link the immune response to joint antigens or other endogenous components although immunization with various cartilage proteins induce arthritis but with different pathogeneses.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 154947-66-7 LL 37

LL 37
(CAS: 154947-66-7)

LL-37 is a cationic and α-helical antimicrobial peptide. It can inhibit growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-d...

CAS 121776-33-8 Furilazole

(CAS: 121776-33-8)

Furilazole, an oxazole derivative, is a herbicide commonly used for gramineous crops.

CAS 110140-89-1 Ridogrel

(CAS: 110140-89-1)

Ridogrel is a thromboxane synthase inhibitor used for the prevention of systemic thrombo-embolism. It is also a receptor antagonist that may be used as an adjun...

CAS 820957-38-8 Retosiban

(CAS: 820957-38-8)

Retosiban is a oxytocin receptor antagonist. It was developed by GlaxoSmithKline for the treatment of preterm labour. Retosiban has high affinity for the oxytoc...

SI-2 hydrochloride

SI-2 hydrochloride is a potent and orally available steroid receptor coactivator 3 (SRC-3) inhibitor. SI-2 has been shown to decrease SRC1, SRC2 and SRC3 levels...

CAS 24316-19-6 Cephalotaxlen

(CAS: 24316-19-6)

Antiviral and antitumor agent.

CAS 1380782-27-3 T2AA

(CAS: 1380782-27-3)

T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor. T2AA inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM), leading to the suppression of DNA re...

CAS 67330-25-0 Ufenamate

(CAS: 67330-25-0)

Ufenamate is a topical analgesic.

CAS 1069046-00-9 ASB14780

(CAS: 1069046-00-9)

ASB14780 is a potent and oral inhibitor of cytosolic phospholipase A2α (cPLA2α; IC50 = 0.020 µM in vitro and 0.54 - 0.64 µM in whole blood assay) with anti-infl...

(CAS: 1286754-10-6)

This molecular is a sulfhydryl and amine reactive heterofuncational PEG linker. The chemical bonds that formed through Maleimide-PEG4-NHS linker are very stable...

CAS 53963-43-2 Ginsenoside F1

Ginsenoside F1
(CAS: 53963-43-2)

Ginsenoside F1, a metabolite of ginsenoside Rg1, which is used as an aldose reductase inhibitor and my exert anti-inflammatory and immunomodulatory activity.

CAS 39262-14-1 Ginsenoside C-K

Ginsenoside C-K
(CAS: 39262-14-1)

Ginsenoside C-K is an intestinal microbiota metabolite of ginsenoside Rb1, which possesses anti-proliferative and anti-inflammatory activities.

CAS 118525-35-2 Sagittatoside A

Sagittatoside A
(CAS: 118525-35-2)

Sagittatoside A is a natural compound isolated from traditional Chinese herb Yinyanghuo.

CAS 1014-70-6 Simetryn

(CAS: 1014-70-6)

Simetryn, a methylthiotriazine derivative, is a herbicide which is commonly used in rice paddy. LC50: 16.9-3.70 mg/L (79.3-17.4 microM).

CAS 329691-12-5 FPR A14

(CAS: 329691-12-5)

FPR A14 is a formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 = 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobiliz...

CAS 14417-88-0 Melinamide

(CAS: 14417-88-0)

Melinamide, also known as AC-223 or Artes, an amide derivative of an unsaturated long-chain fatty acid, is a new hypocholesterolaemic drug, caused a substantial...

CAS 110267-81-7 Amrubicin

(CAS: 110267-81-7)

Amrubicin is a novel anthracycline derivative for treatment of bladder carcinoma.

Cgp 13143
(CAS: 75919-69-6)

Cgp 13143 is a bio-active chemical,but no detailed information has been published yet.

CAS 39011-90-0 Albiflorin

(CAS: 39011-90-0)

Albiflorin is a major constituent presents in peony root, which possesses therapeutic potential for neurodegenerative diseases.

CAS 65-19-0 Yohimbine HCl

Yohimbine HCl
(CAS: 65-19-0)

Yohimbine, an indole alkaloid derived from the bark of the Pausinystalia yohimbe tree in Central Africa, has been used as a mydriatic and in the treatment of im...

Chemical Structure

CAS 35607-20-6 Avridine

Quick Inquiry

Verification code

Featured Items