|Description||AVN-492 is a novel highly-potent and highly-selective 5-HT6R antagonist. The affinity of AVN-492 to bind to 5-HT6R (Ki = 91 pM) was more than three orders of magnitude higher than that to bind to the only other target, 5-HT2BR, (Ki = 170 nM).|
|Solubility||DMSO: ≥ 100 mg/mL|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
8-OH-DPAT (8-Hydroxy-DPAT) is an agonist that has selectivity for 5-HT1A receptor (pIC50 = 8.19). It was subsequently found to be a serotonin reuptake inhibitor...
MK212 hydrochloride is a selective 5-HT2C serotonin receptor agonist. It displays selectivity for 5-HT2C over 5-HT2A with IC50 values of 0.028 and 0.42 μM for h...
(-)-WAY 100135 dihydrochloride
(-)-WAY 100135 dihydrochloride is a selective serotonin 5-HT1A antagonist.
8-Methoxy-2-Aminotetraline hydrochloride is a 5-HT1A agonist.
p-MPPI is a selective 5-HT1A antagonist.
Eletriptan induces concentration-dependent contractions of meningeal artery, coronary artery, and saphenous vein. The potency of Eletriptan is higher in meninge...
Zicronapine, an inden derivative, has been found to be neurotransmitter receptor modulators of sorts of neurotransmitter and was studied against Schizophrenia.
GMC 1-116 is a metabolite of clozapine with weak 5-HT2 affinity and high M1 affinity (IC50 = 27 nM).
Aripiprazole binds with high affinity to both the G protein-coupled and uncoupled states of receptors. Aripiprazole potently activates D2 receptor-mediated inhi...
The hydrochloride salt form of Ziprasidone which is an antagonism of both serotonin and dopamine receptor and could be effective against schizophrenia.
Rizatriptan Benzoate is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.
Velusetrag is a selective, 5-HT4receptor agonist. Phase II clinical trials for the treatment of gastroparesis are on-going. Clnical trials for Alzheimer's disea...
Quetiapine, an thiazepin-analogue of Clozapine, could be effective in the treatment for schizophrenia and major depressive disorder for behaving as a 5HT-2 and ...
Tedatioxetine is an antidepressant agent. It acts as a triple reuptake inhibitor and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist. It was discov...
Cyclobenzaprine HCl is a muscle relaxant, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the sp...
GMC 2-118 is a potent and selective 5-HT1B antagonist.
The citrate salt form of tandospirone, a partial 5HT1A receptors agonist, could be effective as an antianxiety and antidepressant agent.
This active molecular is a Selective 5-HT6 Receptor antagonist, for the treatment of Alzheimer's Disease under development by by Avineuro Pharmaceuticals. AVN-2...
Piboserod hydrochloride is a selective 5-HT4 antagonist.
Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist like other atypical antipsychotic agents. Ziprasidone targets dopamine neurotransmis...