|source\Analogue Sets||Streptomyces | Avermectin Analogue Set|
|Description||The major component (>80%) of a commercially available anthelmintic used to control parasitic nematodes in livestock|
|Purity||>99% by HPLC|
|Synonyms||5-O-Demethylavermectin A1a, C 076B1a.|
|Solubility||Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.|
A rare, boat-shaped, pentacyclic polyketide isolated from several species of streptomyces; exhibits weak antibacterial activity against gram positive and gram n...
A semi-synthetic 4”-epimethylamino analogue of avermectin B1a prepared by oxidation of the 4”-hydroxy moiety and reductive amination
Isolated from streptomyces conglobatus as a potent gram positive antibiotic; exhibits a very high affinity and selectivity for calcium ions as a calcium ionopho...
A close structural analogue of lydicamycin; highly active against MRSA; closely related to BN 4515N which was isolated from a strain of microtetraspora as a neu...
A rare 9,9’-bianthryl antibiotic first isolated from a strain of streptomyces pseudovenezuelae; active against gram positive bacteria, including mycobacteria; h...
A potent inhibitor of IL2 production in a targeted search for novel immunosuppressants; acts by blocking T cell proliferation in vitro by inhibiting the generat...
The major component of the chromomycin complex of the aureolic acid class; isolated from several streptomyces species; exhibits a broad biological profile as an...
A rare nitrophenyl pyranone closely related to aureothin, neoaureothin and its unusual photoisomers SNF4435C and SNF4435D
A semi-synthetic 4”-epimethylamino analogue of avermectin B1b prepared by oxidation of the 4”-hydroxy moiety and reductive amination; members of the avermectin/...
A minor, more hydrophobic analogue of the chromomycin complex of the aureolic acid class; originally isolated from S. Aburaviensis and named aburamycin; exhibit...
The major component (>80%) of the commercial anthelmintic, ivermectin; exert their anthelmintic effects by binding to glutamate-gated chloride channels expresse...
An aminoglycoside antibiotic
A small secondary metabolite formed by the dimerisation of pyrrole-2-carboxylic acid; produced by many streptomyces species; an important dereplication standard...
A minor analogue of the herbimycin complex isolated from streptomyces hygroscopicus; possesses potent antitumour activity and converts rous sarcoma virus-infect...
A family of lipophilic nucleosides with fatty acids conjugated to an aminoglycoside group; act by blocking the formation of N-glycoside linkages to proteins via...
An unusual pyrollic ionophore active against gram positive bacteria and insects; has antihypertensive properties; a growth promoter in ruminants.
A minor member of the leptomycin complex isolated from some streptomyces species; an hydroxylated analogue of leptomycin B, a nuclear export inhibitor; exhibits...
The major component (>80%) of a commercially available anthelmintic used to control parasitic nematodes in livestock
A nucleoside antibiotic isolated from streptomyces alboniger; an anti-trypansomal agent with antibiotic activity; non-selective, inhibiting RNA by blocking ribo...
A member of the macrotetrolide complex produced by a range of streptomyces species; a monovalent cation ionophore with high selectivity for ammonium and potassi...