|Description||Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.|
Aldoxorubicin is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity.
HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in ...
After an IV dose of 20a at 20 μg/kg to Wistar Han rats, PF-06380101 exhibited a mean systemic clearance (Cl) of 70 mL/min/kg and a volume of distribution (Vss) ...
Ansamitocin P-3, a metabolite of Ansamitocin, displays potent cytotoxicity against as a a new maytansinoid antitumor antibiotic.
alpha-Amanitin, the major toxic bicyclic octapeptide of the mushroom Amanita phalloides, inhibits RNA polymerase II at 1 µg/ml, RNA polymerase III at 10 µg/ml a...
Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.
Calicheamicin, also known as Calichemicin γ1, is an potent enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora. Calicheamicin t...
Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. It is chemotherapeutic of the anthracycline family that is g...
Methotrexate, a folate antagonist, is a potent anti-inflammatory agent when used weekly in low concentrations, the anti-phlogistic action of which is due to inc...
Triptolide is a diterpenoid epoxide found in the Thunder God Vine, Tripterygium wilfordii, which has been used in traditional Chinese medicine for more than two...
Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila used in the preparation of site-specific trastuzumab maytansinoid antibody-drug...
Dolastatin 10 is an inhibitior of microtubule disassembly (IC50= 1.2μM) and potently inhibits vincristine binding to tubulin in a noncompetitive manner ( Ki= 1....
Daunomycin is an important anti-tumor agent, mainly used in the treatment of acute leukemias. Daunomycin can inhibit DNA synthesis by the way of binding to DNA(...
MMAE, whose full name is Monomethyl auristatin E, inhibits tubulin polymerization so that it inhibits cell division.
MMAF is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin and it has lower cytotoxic activity than MMAE. It is an antibo...
Taxol, also called Paclitaxel, derived from the bark of the Pacific yew tree, has a broad antineoplastic spectrum uused in cancer chemotherapy.It promotes and s...
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility. It induced mitotic cell cycle ar...
Ansamitocin P-3, a potent anti-tumor maytansinoid found in Actinosynnema pretiosum, is a maytansine analog which displays potent cytotoxicity against the human ...
Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.
Tubulysin A is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays. Tubulysin A is a novel antibiotic, which is anti-mi...