Auristatin F - CAS 163768-50-1
Catalog number:
163768-50-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C40H67N5O8
Molecular Weight:
745.99
COA:
Inquire
Targets:
ADCs Cytotoxin
Description:
Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Auristatin F
MSDS:
Inquire
1.An anti-HER2 antibody conjugated with monomethyl auristatin E is highly effective in HER2-positive human gastric cancer.
Li H1, Yu C2, Jiang J3, Huang C2, Yao X1, Xu Q2, Yu F2, Lou L4, Fang J1,5,6. Cancer Biol Ther. 2016 Apr 2;17(4):346-54. doi: 10.1080/15384047.2016.1139248. Epub 2016 Feb 6.
Antibody-drug conjugate (ADC) is a novel class of therapeutics for cancer target therapy. This study assessed antitumor activity of ADC with an antimitotic agent, monomethyl auristatin E (MMAE) and a humanized monoclonal anti-HER2 antibody, hertuzumab, in gastric cancer. The efficacy of hertuzumab-MC-Val-Cit-PAB-MMAE (hertuzumab-vcMMAE) on human epidermal growth factor receptor 2 (HER2) positive human gastric cancer cells, NCI-N87, was evaluated in vitro and in vivo. The cytotoxicity of hertuzumab was significantly enhanced after conjugation with MMAE. Compared to trastuzumab, hertuzumab had a higher affinity to HER2 and had more potent antibody-dependent cell-mediated cytotoxicity (ADCC) activity in vitro. After conjugation with MMAE, the binding specificity for HER2 was not affected. Furthermore, the internalization of hertuzumab-vcMMAE in HER2 positive gastric cancer cells was verified. Although the conjugation of hertuzumab and MMAE decreased the ADCC effect, the overall cytotoxicity was dramatically increased in HER2 positive gastric cancer cells.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related ADCs Cytotoxin Products


Aldoxorubicin hydrochloride
(CAS: 480998-12-7)

Aldoxorubicin is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity.

CAS 228266-41-9 Taltobulin trifluoroacetate

Taltobulin trifluoroacetate
(CAS: 228266-41-9)

HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines (mean IC50 = 2 nmol/L +/- 1 nmol/L) in vitro. Interestingly, no decrease in ...

CAS 1436391-86-4 PF-06380101

PF-06380101
(CAS: 1436391-86-4)

After an IV dose of 20a at 20 μg/kg to Wistar Han rats, PF-06380101 exhibited a mean systemic clearance (Cl) of 70 mL/min/kg and a volume of distribution (Vss) ...

CAS 66584-72-3 Ansamitocin P-3

Ansamitocin P-3
(CAS: 66584-72-3)

Ansamitocin P-3, a metabolite of Ansamitocin, displays potent cytotoxicity against as a a new maytansinoid antitumor antibiotic.

CAS 23109-05-9 alpha-Amanitin

alpha-Amanitin
(CAS: 23109-05-9)

alpha-Amanitin, the major toxic bicyclic octapeptide of the mushroom Amanita phalloides, inhibits RNA polymerase II at 1 µg/ml, RNA polymerase III at 10 µg/ml a...

CAS 160800-57-7 Auristatin E

Auristatin E
(CAS: 160800-57-7)

Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.

CAS 108212-75-5 Calicheamicin

Calicheamicin
(CAS: 108212-75-5)

Calicheamicin, also known as Calichemicin γ1, is an potent enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora. Calicheamicin t...

CAS 23541-50-6 Daunorubicin hydrochloride

Daunorubicin hydrochloride
(CAS: 23541-50-6)

Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. It is chemotherapeutic of the anthracycline family that is g...

CAS 59-05-2 Methotrexate

Methotrexate
(CAS: 59-05-2)

Methotrexate, a folate antagonist, is a potent anti-inflammatory agent when used weekly in low concentrations, the anti-phlogistic action of which is due to inc...

CAS 38748-32-2 Triptolide

Triptolide
(CAS: 38748-32-2)

Triptolide is a diterpenoid epoxide found in the Thunder God Vine, Tripterygium wilfordii, which has been used in traditional Chinese medicine for more than two...

CAS 57103-68-1 Maytansinol

Maytansinol
(CAS: 57103-68-1)

Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila used in the preparation of site-specific trastuzumab maytansinoid antibody-drug...

CAS 110417-88-4 Dolastatin 10

Dolastatin 10
(CAS: 110417-88-4)

Dolastatin 10 is an inhibitior of microtubule disassembly (IC50= 1.2μM) and potently inhibits vincristine binding to tubulin in a noncompetitive manner ( Ki= 1....

CAS 290304-24-4 Daun02

Daun02
(CAS: 290304-24-4)

Daunomycin is an important anti-tumor agent, mainly used in the treatment of acute leukemias. Daunomycin can inhibit DNA synthesis by the way of binding to DNA(...

CAS 474645-27-7 MMAE

MMAE
(CAS: 474645-27-7)

MMAE, whose full name is Monomethyl auristatin E, inhibits tubulin polymerization so that it inhibits cell division.

CAS 745017-94-1 MMAF

MMAF
(CAS: 745017-94-1)

MMAF is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin and it has lower cytotoxic activity than MMAE. It is an antibo...

CAS 33069-62-4 Taxol

Taxol
(CAS: 33069-62-4)

Taxol, also called Paclitaxel, derived from the bark of the Pacific yew tree, has a broad antineoplastic spectrum uused in cancer chemotherapy.It promotes and s...

CAS 90332-63-1 10-Deacetyl-7-xylosyl paclitaxel

10-Deacetyl-7-xylosyl paclitaxel
(CAS: 90332-63-1)

10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility. It induced mitotic cell cycle ar...

CAS 66547-09-9 Ansamitocin P-3

Ansamitocin P-3
(CAS: 66547-09-9)

Ansamitocin P-3, a potent anti-tumor maytansinoid found in Actinosynnema pretiosum, is a maytansine analog which displays potent cytotoxicity against the human ...

CAS 163768-50-1 Auristatin F

Auristatin F
(CAS: 163768-50-1)

Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.

CAS 205304-86-5 Tubulysin A

Tubulysin A
(CAS: 205304-86-5)

Tubulysin A is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays. Tubulysin A is a novel antibiotic, which is anti-mi...

Chemical Structure

CAS 163768-50-1 Auristatin F

Quick Inquiry

Verification code

Featured Items