Aucubin - CAS 479-98-1
Catalog number:
479-98-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H22O9
Molecular Weight:
346.33
COA:
Inquire
Targets:
Others
Description:
Aucubin is an iridoid glycoside with a wide range of biological activities, including anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities. It may be a potential therapeutic choice in the treatment of OA due to its anti-inflamm
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥98%
Appearance:
White powder
Synonyms:
(2S,3R,4S,5S,6R)-2-[[(1S,4aR,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Anti-inflammatory/chondroprotective
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
InChIKey:
RJWJHRPNHPHBRN-FKVJWERZSA-N
InChI:
1S/C15H22O9/c16-4-6-3-8(18)7-1-2-22-14(10(6)7)24-15-13(21)12(20)11(19)9(5-17)23-15/h1-3,7-21H,4-5H2/t7-,8+,9+,10+,11+,12-,13+,14-,15-/m0/s1
Canonical SMILES:
C1=COC(C2C1C(C=C2CO)O)OC3C(C(C(C(O3)CO)O)O)O
1.In Vitro Effects of Plantago Major Extract, Aucubin, and Baicalein on Candida Albicans Biofilm Formation, Metabolic Activity, and Cell Surface Hydrophobicity.
Shirley KP1, Windsor LJ2, Eckert GJ3, Gregory RL2. J Prosthodont. 2015 Nov 30. doi: 10.1111/jopr.12411. [Epub ahead of print]
PURPOSE: To determine the in vitro effectiveness of Plantago major extract, along with two of its active components, aucubin and baicalein, on the inhibition of Candida albicans growth, biofilm formation, metabolic activity, and cell surface hydrophobicity.
2.Pharmacokinetics and tissue distribution of Aucubin, Ajugol and Catalpol in rats using a validated simultaneous LC-ESI-MS/MS assay.
Xue B1, Ma B2, Zhang Q3, Li X4, Zhu J2, Liu M2, Wu X2, Wang C2, Wu Z5. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:245-53. doi: 10.1016/j.jchromb.2015.08.026. Epub 2015 Aug 28.
To enable an investigation of pharmacokinetics and tissue distribution of Aucubin, Ajugol and Catalpol in rats, a high-performance liquid chromatography-electro spray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed for the simultaneous quantitative determination of the three compounds. Biological samples were prepared by a simple protein precipitation with methanol (containing 0.05% formic acid). The analytes were separated by a C18 reversed phase column and detected with a triple quadrupole tandem mass spectrometer in the multiple-reaction monitoring (MRM) mode to monitor the precursor-to-product ion transitions of m/z 364.3→149.0 for Aucubin, m/z 366.5→151.1 for Ajugol, m/z 380.0→183.3 for Catalpol and m/z 530.3→183.1 for Picroside-II (IS) in positive ionization. Good linearity of each calibration curve was produced over the concentration range of 1-1000ng/mL. The lower limit of quantification (LLOQ) was 1ng/mL for the three analytes.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 102841-42-9 Mulberroside A

Mulberroside A
(CAS: 102841-42-9)

Mulberroside A, extracted from the root bark of white mulberry, could reduce P-gp expression and function being along with the activation of PKC and NF-κB. It h...

CAS 1515856-92-4 XEN445

XEN445
(CAS: 1515856-92-4)

XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.

Rabies Virus Glycoprotein

Rabies Virus Glycoprotein, a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein, is only structural protein of the virus that induc...

CAS 21738-42-1 Oxamniquine

Oxamniquine
(CAS: 21738-42-1)

Oxamniquine, with schistosomicidal activity, is an antischistosomal drug used in the treatment of Schistosoma mansoni infection.

CP-74667
(CAS: 108461-05-8)

CP-74667 is a new fluoroquinolone compound. It has good activity against several gram-positive and gram-negative pathogens.

CAS 218137-86-1 C75

C75
(CAS: 218137-86-1)

C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and ca...

CAS 122008-78-0 Cyhalofop

Cyhalofop
(CAS: 122008-78-0)

Cyhalofop(Cyhalofop acid) is a recently registered herbicide from the aryloxyphenoxy propionate group in India to control a wide range of grass weed species at ...

CAS 34597-40-5 Fenoprofen Calcium

Fenoprofen Calcium
(CAS: 34597-40-5)

Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.

CAS 1126-61-0 4-Allylcatechol

4-Allylcatechol
(CAS: 1126-61-0)

4-Allylcatechol is an intermediate to synthetic safrole and was used in a study performed to evaluate the phenolic content, antioxidant and antimicrobial activi...

CAS 37640-71-4 Aprindine

Aprindine
(CAS: 37640-71-4)

Aprindine is a Class 1b antiarrhythmic agent as a cardiac depressant used in arrhythmias.

Glutaminase C-IN-1
(CAS: 311795-38-7)

Glutaminase C-IN-1, with effect to suppresse breast cancer cell growth and invasive activity in vitro, it is an allosteric, cell-permeable and reversible inhibi...

EPZ020411
(CAS: 1700663-41-7)

EPZ020411, with potent anticancer activity, is an orally bioactive, selective inhibitor of PRMT6/8/1 with over 100-fold selective for other histone methyltransf...

SR9009
(CAS: 1379686-30-2)

SR9009, an analogue of SR9011, has similar effect for having probable effect against sleep disorders and metabolic diseases. IC50: 670 nM and 800 nM for Rev-Erb...

FR-182980
(CAS: 179054-51-4)

FR-182980, a pyridine derivative, has been found to be a sterol O-acyltransferase inhibitor and was once studied in hypercholesterolaemia.

CAS 132-69-4 Benzydamine Hydrochloride

Benzydamine Hydrochloride
(CAS: 132-69-4)

Benzydamine hydrochlorid is structurally unrelated to the corticosteroids. The action of benzydamine may be mediated by the prostaglandin system.

CAS 9004-82-4 Sodium lauryl polyoxyethylene ether sulfate

Sodium lauryl polyoxyethylene ether sulf
(CAS: 9004-82-4)

Sodium lauryl polyoxyethylene ether sulfate is an anionic detergent and surfactant found in many personal care products, such as soaps, shampoos, toothpaste etc...

CAS 60-80-0 Antipyrine

Antipyrine
(CAS: 60-80-0)

Antipyrine is an analgesic, a non-steroidal anti-inflammatory drug and an antipyretic.

CAS 112809-51-5 Letrozole

Letrozole
(CAS: 112809-51-5)

Letrozole is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM.

FR-64822
(CAS: 102671-35-2)

FR-64822 is a novel non-opioid antinociceptive compound. It has antinociceptive activities in a variety of assays in mice and rats. It also has a strong antinoc...

CAS 682741-29-3 HTS01037

HTS01037
(CAS: 682741-29-3)

HTS01037, a high-affinity ligand of adipocyte fatty acid binding protein (A-FABP/aP2) (Ki = 0.67 μM), and is a competitive antagonist of protein-protein interac...

Chemical Structure

CAS 479-98-1 Aucubin

Quick Inquiry

Verification code

Featured Items