|Description||ATR-101 is a selective Acetyl CoA C-acetyltransferase inhibitor. ATR-101 is uniquely distributed to adrenal tissues and inhibition of adrenal ACAT1 by ATR-101 disrupts steroidogenesis and leads to selective apoptosis of steroid producing adrenocortical-derived cells. Phase-II clinical trials in Congenital adrenal hyperplasia in USA was on-going. In addiction, Phase I clinical trials in Adrenocortical carcinoma was on-going too.|
|Synonyms||UNII-VK9OS8R205;N-(2,6-Bis(isopropyl)phenyl)-N'-((1-(4-(dimethylaminomethyl)phenyl)cyclopentyl)methyl)urea;Damp-cmumep; PD-132301;133825-81-7 (ATR-101 HCl)|
|Solubility||Soluble in DMSO|
|Application||Congenital adrenal hyperplasia;Adrenocortical carcinoma|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Millendo Therapeutics|
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