ATPA - CAS 140158-50-5
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C10H16N2O4
Molecular Weight:
228.25
COA:
Inquire
Targets:
mGluR
Description:
ATPA is a potent and selective GluR5 kainate receptor agonist with Ki value of 4.3 nM. It is weakly active at AMPA receptors (GluR1-4), GluR7 and the kainate receptors KA-2.
Purity:
≥98% by HPLC
Synonyms:
(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
MSDS:
Inquire
InChIKey:
PIXJURSCCVBKRF-UHFFFAOYSA-N
InChI:
InChI=1S/C10H16N2O4/c1-10(2,3)7-5(8(13)12-16-7)4-6(11)9(14)15/h6H,4,11H2,1-3H3,(H,12,13)(H,14,15)
Canonical SMILES:
CC(C)(C)C1=C(C(=O)NO1)CC(C(=O)O)N
1.Electrophysiological effects of kainic acid on vasopressin-enhanced green fluorescent protein and oxytocin-monomeric red fluorescent protein 1 neurones isolated from the supraoptic nucleus in transgenic rats.
Ohkubo J1, Ohbuchi T, Yoshimura M, Maruyama T, Ishikura T, Matsuura T, Suzuki H, Ueta Y. J Neuroendocrinol. 2014 Jan;26(1):43-51. doi: 10.1111/jne.12128.
The supraoptic nucleus (SON) contains two types of magnocellular neurosecretory cells: arginine vasopressin (AVP)-producing and oxytocin (OXT)-producing cells. We recently generated and characterised two transgenic rat lines: one expressing an AVP-enhanced green fluorescent protein (eGFP) and the other expressing an OXT-monomeric red fluorescent protein 1 (mRFP1). These transgenic rats enable the visualisation of AVP or OXT neurones in the SON. In the present study, we compared the electrophysiological responses of AVP-eGFP and OXT-mRFP1 neurones to glutamic acid in SON primary cultures. Glutamate mediates fast synaptic transmission through three classes of ionotrophic receptors: the NMDA, AMPA and kainate receptors. We investigated the contributions of the three classes of ionotrophic receptors in glutamate-induced currents. Three different antagonists were used, each predominantly selective for one of the classes of ionotrophic receptor.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related mGluR Products


CAS 56-85-9 L-Glutamine

L-Glutamine
(CAS: 56-85-9)

L-Glutamine is one of the 20 amino acids encoded by the standard genetic code.

CAS 31932-87-3 (RS)-3-Hydroxyphenylglycine

(RS)-3-Hydroxyphenylglycine
(CAS: 31932-87-3)

(RS)-3-Hydroxyphenylglycine is an agonist at PI-linked metabotropic glutamate receptors.

CAS 1401031-52-4 LSN 2463359

LSN 2463359
(CAS: 1401031-52-4)

LSN 2463359 is an allosteric modulator at the mGlu5 receptor with EC50 value of 24 nM. It is brain penetrant and can reverse learning deficits in a rat model of...

CAS 1311385-32-6 LY2979165

LY2979165
(CAS: 1311385-32-6)

LY2979165 is a mGlu2 agonist, which is a novel potent agent that is used as anti-depressants.

CAS 781652-57-1 CDPPB

CDPPB
(CAS: 781652-57-1)

CDPPB is a positive allosteric modulator of mGlu5 receptor (EC50 = 10 and 20 nM for human and rat receptors, respectively). Study shows that CDPPB has a therape...

CAS 1303994-09-3 (RS)-MCPG Disodium Salt

(RS)-MCPG Disodium Salt
(CAS: 1303994-09-3)

(RS)-MCPG disodium salt is a non-selective group I/II metabotropic glutamate receptor antagonist.

ML337
(CAS: 1443118-44-2)

ML337 is a Selective negative allosteric modulator of mGlu3 with IC50 value of 593 nM. It shows no activity at mGlu1, mGlu2 or mGlu4-8 at concentrations up to 3...

CAS 162870-29-3 (S)-3,5-DHPG

(S)-3,5-DHPG
(CAS: 162870-29-3)

(S)-3,5-DHPG is a selective group I mGluR agonist used for the treatment of neuronal injury and cognitive enhancement.

Chemical Structure

CAS 140158-50-5 ATPA

Quick Inquiry

Verification code

Featured Items