ATPA - CAS 140158-50-5
Category: Inhibitor
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Molecular Formula:
C10H16N2O4
Molecular Weight:
228.25
COA:
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Targets:
mGluR
Description:
ATPA is a potent and selective GluR5 kainate receptor agonist with Ki value of 4.3 nM. It is weakly active at AMPA receptors (GluR1-4), GluR7 and the kainate receptors KA-2.
Purity:
≥98% by HPLC
Synonyms:
(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
MSDS:
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InChIKey:
PIXJURSCCVBKRF-UHFFFAOYSA-N
InChI:
InChI=1S/C10H16N2O4/c1-10(2,3)7-5(8(13)12-16-7)4-6(11)9(14)15/h6H,4,11H2,1-3H3,(H,12,13)(H,14,15)
Canonical SMILES:
CC(C)(C)C1=C(C(=O)NO1)CC(C(=O)O)N
1.Electrophysiological effects of kainic acid on vasopressin-enhanced green fluorescent protein and oxytocin-monomeric red fluorescent protein 1 neurones isolated from the supraoptic nucleus in transgenic rats.
Ohkubo J1, Ohbuchi T, Yoshimura M, Maruyama T, Ishikura T, Matsuura T, Suzuki H, Ueta Y. J Neuroendocrinol. 2014 Jan;26(1):43-51. doi: 10.1111/jne.12128.
The supraoptic nucleus (SON) contains two types of magnocellular neurosecretory cells: arginine vasopressin (AVP)-producing and oxytocin (OXT)-producing cells. We recently generated and characterised two transgenic rat lines: one expressing an AVP-enhanced green fluorescent protein (eGFP) and the other expressing an OXT-monomeric red fluorescent protein 1 (mRFP1). These transgenic rats enable the visualisation of AVP or OXT neurones in the SON. In the present study, we compared the electrophysiological responses of AVP-eGFP and OXT-mRFP1 neurones to glutamic acid in SON primary cultures. Glutamate mediates fast synaptic transmission through three classes of ionotrophic receptors: the NMDA, AMPA and kainate receptors. We investigated the contributions of the three classes of ionotrophic receptors in glutamate-induced currents. Three different antagonists were used, each predominantly selective for one of the classes of ionotrophic receptor.
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CAS 140158-50-5 ATPA

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