Atopaxar - CAS 751475-53-3
Catalog number:
751475-53-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C29H38FN3O5
Molecular Weight:
527.64
COA:
Inquire
Targets:
Protease-Activated Receptors (PARs)
Description:
Atopaxar is a Protease-activated receptor-1 (PAR-1) inhibitor. It can inhibit the binding of a high-affinity thrombin receptor-activating peptide ([(3)H]haTRAP) to PAR-1 with IC50 value of 0.019μM. Atopaxar exhibits potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 values of 0.064 and 0.031μM. It may become a therapeutic option for atherothrombotic disease. In May 2012, Phase-II for Acute coronary syndromes in European Union was discontinued.
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Purity:
98%
Appearance:
Powder
Synonyms:
E 5555; ER-172594-00; ER172594-00; ER 172594-00; Atopaxar;1-(3-(tert-butyl)-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethan-1-one;474550-69-1(hydrobromide)
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
Acute coronary syndromes;
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
QWKAUGRRIXBIPO-UHFFFAOYSA-N
InChI:
1S/C29H38FN3O5/c1-7-37-23-15-19-16-33(28(31)24(19)25(30)27(23)38-8-2)17-22(34)18-13-20(29(3,4)5)26(35-6)21(14-18)32-9-11-36-12-10-32/h13-15,31H,7-12,16-17H2,1-6H3
Canonical SMILES:
CCOc1cc2CN(CC(=O)c3cc(N4CCOCC4)c(OC)c(c3)C(C)(C)C)C(=N)c2c(F)c1OCC
Current Developer:
Originator Eisai Co Ltd
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