Atipamezole hydroChloride - CAS 104075-48-1
Catalog number: 104075-48-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C14H16N2.HCl
Molecular Weight:
248.75
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
The hydrochloride salt form of atipamezole that is an alpha2-adrenoceptor blocker which could be used for animals to recover from the anesthesia by lowering blood pressure and increasing heart rate and breathing rate.
Purity:
>99 %
Appearance:
White Solid
Synonyms:
1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride;Atipamezole HCL;4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride;4-(2-Ethyl-2-indanyl)imidazole hydrochloride;Atipamezole hydrochloride;Unii-2W4279571x
Solubility:
DMSO > 47mg/ml
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
The hydrochloride salt form of atipamezole that is an alpha2-adrenoceptor blocker which could be used for animals to recover from the anesthesia by lowering blood pressure and increasing heart rate and breathing rate.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
367.1ºC at 760mmHg
Melting Point:
216-219°C
Density:
1.115g/cm3
InChIKey:
PCCVCJAQMHDWJY-UHFFFAOYSA-N
InChI:
1S/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H
Canonical SMILES:
CCC1(C2=CN=CN2)CC3=CC=CC=C3C1.Cl
1.Anesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine, ketamine injection in dogs.
Ueyama Y1, Waselau AC, Wiese AJ, Muir WW. Vet Anaesth Analg. 2008 Nov;35(6):480-7. doi: 10.1111/j.1467-2995.2008.00415.x. Epub 2008 Aug 15.
OBJECTIVE: To determine the quality and duration of anesthesia and the cardiopulmonary effects of a morphine, medetomidine, ketamine (MMK) combination administered intramuscularly (IM) to dogs.
2.Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain.
Finnema SJ1, Hughes ZA2, Haaparanta-Solin M2, Stepanov V2, Nakao R2, Varnäs K2, Varrone A2, Arponen E2, Marjamäki P2, Pohjanoksa K2, Vuorilehto L2, Babalola PA2, Solin O2, Grimwood S2, Sallinen J2, Farde L2, Scheinin M2, Halldin C2. Int J Neuropsychopharmacol. 2014 Dec 13;18(3). pii: pyu081. doi: 10.1093/ijnp/pyu081.
BACKGROUND: The neurotransmitter norepinephrine has been implicated in psychiatric and neurodegenerative disorders. Examination of synaptic norepinephrine concentrations in the living brain may be possible with positron emission tomography (PET), but has been hampered by the lack of suitable radioligands.
3.Effects of alpha-adrenergic agonists on pain modulation in diffuse noxious inhibitory control.
Sanada T1, Kohase H, Makino K, Umino M. J Med Dent Sci. 2009 Mar;56(1):17-24.
BACKGROUND: Diffuse noxious inhibitory control (DNIC) is thought to be mediated by neural networks in supraspinal brain structures. The descending antinociceptive system (DAS) is an important component of the DNIC neural network, but the precise structure of the neural network and the related neurotransmitters have not been examined.
4.Effects of a medetomidine-ketamine combination on Schirmer tear test I results of clinically normal cats.
Di Pietro S, Macrì F, Bonarrigo T, Giudice E, Palumbo Piccionello A, Pugliese A. Am J Vet Res. 2016 Mar;77(3):310-4. doi: 10.2460/ajvr.77.3.310.
OBJECTIVE To evaluate the effects of a medetomidine-ketamine combination on tear production of clinically normal cats by use of the Schirmer tear test (STT) 1 before and during anesthesia and after reversal of medetomidine with atipamezole. ANIMALS 40 client-owned crossbred domestic shorthair cats (23 males and 17 females; age range, 6 to 24 months). PROCEDURES A complete physical examination, CBC, and ophthalmic examination were performed on each cat. Cats with no abnormalities on physical and ophthalmic examinations were included in the study. Cats were allocated into 2 groups: a control group (n = 10 cats) anesthetized by administration of a combination of medetomidine hydrochloride (80 μg/kg) and ketamine hydrochloride (5 mg/kg), and an experimental group (30) anesthetized with the medetomidine-ketamine combination and reversal by administration of atipamezole. Tear production of both eyes of each cat was measured by use of the STT I before anesthesia, 15 minutes after the beginning of anesthesia, and 15 minutes after administration of atipamezole.
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CAS 104075-48-1 Atipamezole hydroChloride

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