ATB 346 - CAS 1226895-20-0
Catalog number: 1226895-20-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Targets:
COX
Publictions citing BOC Sciences Products
  • >> More
MSDS:
Inquire
1.The hydrogen sulfide releasing compounds ATB-346 and diallyl trisulfide attenuate streptozotocin-induced cognitive impairment, neuroinflammation, and oxidative stress in rats: involvement of asymmetric dimethylarginine.
Mostafa DK1, El Azhary NM2, Nasra RA3. Can J Physiol Pharmacol. 2016 Jan 20:1-10. [Epub ahead of print]
Hydrogen sulfide (H2S) has attracted interest as a gaseous mediator involved in diverse processes in the nervous system, particularly with respect to learning and memory. However, its therapeutic potential in Alzheimer disease (AD) is not fully explored. Therefore, the effects of H2S-releasing compounds against AD-like behavioural and biochemical abnormalities were investigated. Memory deficit was induced by intracerberoventicular injection of streptozotocin (STZ, 3 mg·kg-1). Animals were randomly assigned into 5 groups (12 rats each): normal control, STZ treated, and 3 drug-treated groups receiving naproxen, H2S-releasing naproxen (ATB-346), and diallyl trisulfide in 20, 32, 40 mg·kg-1·day-1, respectively. Memory function was assessed by passive avoidance and T-maze tasks. After 21 days, hippocampal IL-6, malondialdehyde, reduced glutathione (GSH), asymmetric dimethylarginine (ADMA), and acetylcholinestrase activity were determined. ATB-346 and diallyl trisulfide ameliorated behavioural performance and reduced malondialdehyde, ADMA, and acetylcholinestrase activity while increasing GSH.
2.Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice.
Campolo M1, Esposito E2, Ahmad A3, Di Paola R4, Paterniti I5, Cordaro M6, Bruschetta G7, Wallace JL8, Cuzzocrea S9,10. J Neuroinflammation. 2014 Dec 4;11:196. doi: 10.1186/s12974-014-0196-1.
BACKGROUND: Traumatic brain injury (TBI) induces secondary injury mechanisms, including dynamic interplay between ischemic, inflammatory and cytotoxic processes. We recently reported that administration of ATB-346 (2-(6-methoxynapthalen- 2-yl)-propionic acid 4-thiocarbamoyl-phenyl ester), a hydrogen sulfide-releasing cyclooxygenase inhibitor, showed marked beneficial effects in an animal model of spinal cord injury, significantly enhancing recovery of motor function and reducing the secondary inflammation and tissue injury.
3.The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis.
Herrera BS1, Coimbra LS2, da Silva AR3, Teixeira SA3, Costa SK3, Wallace JL4, Spolidorio LC2, Muscara MN3. Med Gas Res. 2015 Feb 27;5:4. doi: 10.1186/s13618-015-0025-3. eCollection 2015.
BACKGROUND: In experimental periodontitis, non-steroidal antiinflammatory drugs (NSAIDs) effectively inhibit the resultant alveolar bone loss. However, their deleterious gastric effects, observed in both animals and humans, dramatically limit their long-term use. It has been proven that the addition of a hydrogen sulfide (H2S)-releasing moiety to classical NSAID structures results in antiinflammatory compounds with improved gastric safeness. In this way, we decided to compare the effects of naproxen with its H2S-releasing derivative ATB-346 on ligature-induced periodontitis in rats.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related COX Products


CAS 103-90-2 Acetaminophen

Acetaminophen
(CAS: 103-90-2)

A selective COX-2 inhibitor

CAS 19210-12-9 Harpagoside

Harpagoside
(CAS: 19210-12-9)

Harpagoside, isolated from the Harpagophytum procumbens (Devil's Claw) root or Crophularia ningpoensis Hemsl (Figwort), inhibited lipopolysaccharide-induced mRN...

CAS 116686-15-8 FK 3311

FK 3311
(CAS: 116686-15-8)

A selective COX-2 inhibitor

CAS 198470-85-8 Parecoxib Sodium

Parecoxib Sodium
(CAS: 198470-85-8)

The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells an...

CAS 853-34-9 Kebuzone

Kebuzone
(CAS: 853-34-9)

Kebuzone is a non-steroidal anti-inflammatory drug. It also has analgesic, antipyretic, and platelet-inhibitory activities. Kebuzone is a cyclooxygenase inhibit...

CAS 162011-90-7 Rofecoxib

Rofecoxib
(CAS: 162011-90-7)

A COX-2 inhibitor( IC50s = 26 nM and > 50 µM in human osteosarcoma cells )

CAS 50-78-2 Aspirin

Aspirin
(CAS: 50-78-2)

A salicylate and irreversible COX1 and COX2 inhibitor

CAS 5907-38-0 Analgin

Analgin
(CAS: 5907-38-0)

Analgin, is an non-opioid analgesic (pain reliever) and antipyretic (fever reducer) and is one of the most frequently used painkillers in the world.

CAS 189954-96-9 Firocoxib

Firocoxib
(CAS: 189954-96-9)

A selective COX-2 inhibitor

CAS 51803-78-2 Nimesulide

Nimesulide
(CAS: 51803-78-2)

A selective COX-2 inhibitor

CAS 120210-48-2 Tenidap

Tenidap
(CAS: 120210-48-2)

Tenidap is one of the nonsteroidal antiinflammatory drugs. It is a COX1/2 and 5-lipoxygenase inhibitor. Tenidap preferentially inhibits COX-1 and IC50 value is...

CAS 181695-72-7 Valdecoxib

Valdecoxib
(CAS: 181695-72-7)

A selective COX-2 inhibitor

CAS 53-86-1 Indomethacin

Indomethacin
(CAS: 53-86-1)

A nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively

CAS 18524-94-2 Loganin

Loganin
(CAS: 18524-94-2)

Loganin, isolated from the seeds of Strychnos nux-vomica, is an iridoid glycoside inhibitor of Cox-1 and it shows antioxidant, hepatoprotective, and neuroprotec...

FR 122047 hydrochloride
(CAS: 130717-51-0)

FR-122047 is a selective cyclooxygenase-1 (COX-1) inhibitor with IC50 values is 0.028μM for COX-1 and 65 μM for COX-2. FR-122047 displays 2300 fold greater sele...

CAS 36322-90-4 Piroxicam

Piroxicam
(CAS: 36322-90-4)

Piroxicam is a non-selective COX inhibitor with an IC50 of 6 mM.

BMS-347070
(CAS: 197438-73-6)

BMS-347070 is a COX-2 inhibitor, initially developed for the treatment for Colorectal cancer.

CAS 22204-53-1 Naproxen

Naproxen
(CAS: 22204-53-1)

(S)-Naproxen is a non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. It is an anti-in...

CAS 322-79-2 Triflusal

Triflusal
(CAS: 322-79-2)

Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.

CAS 53164-05-9 Acemetacin

Acemetacin
(CAS: 53164-05-9)

COX inhibitor; A non-steroidal anti-inflammatory drug

Chemical Structure

CAS 1226895-20-0 ATB 346

Quick Inquiry

Verification code

Featured Items