AT406 (SM-406, ARRY-334543) - CAS 1071992-99-8
Catalog number:
1071992-99-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C32H43N5O4
Molecular Weight:
561.71
COA:
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Targets:
XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3
Description:
AT406 (SM-406, ARRY-334543) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3 (with Ki of 66.4 nM), cIAP1-BIR3(with Ki of 1.9 nM) and cIAP2-BIR3 ( with Ki of 5.1 nM), respectively. Phase 1.
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Purity:
98%
Appearance:
Solid powder
Synonyms:
AT-406 (SM-406); AT406 (SM-406, ARRY-334543);
Solubility:
DMSO,100mg/mL(178.02mM);Ethanol,100mg/mL(178.02mM);Water,<1mg/mL(<1mM)
Storage:
3 years -20℃powder;6 months-80℃in solvent
MSDS:
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Shelf Life:
2 years if stored properly
Canonical SMILES:
CC(CC(N(C[C@@](/N=C(O)/[C@](NC)([H])C)([H])C1=O)CC[C@@](N21)([H])CC[C@@]2([H])/C(O)=N/C(C3=CC=CC=C3)C4=CC=CC=C4)=O)C
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CAS 1071992-99-8 AT406 (SM-406, ARRY-334543)

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