AT101 - CAS 90141-22-3
Catalog number: 90141-22-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H30O8·C2H4O2
Molecular Weight:
578.6
COA:
Inquire
Targets:
Bcl-2 Family
Description:
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
AT-101
MSDS:
Inquire
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Bcl-2 Family Products


A-1155463
(CAS: 1235034-55-5)

A-1155463, an effective and selective BCL-XL inhibitor, has been studied to have probable effect in restraining the growth of small cell lung cancer xenograft t...

CAS 1430844-80-6 A-1331852

A-1331852
(CAS: 1430844-80-6)

A-1331852, a substituted benzothiazole, is a high affinity BH3 mimetic Ligand of BCL protein BCL-XL (Ki≤ 10 pM). A-1331852 is an orally apoptosis-inducing agent...

CAS 65673-63-4 HA14-1

HA14-1
(CAS: 65673-63-4)

CAS 579492-81-2 Bax inhibitor peptide V5

Bax inhibitor peptide V5
(CAS: 579492-81-2)

Bax inhibitor peptide V5, a peptide inhibitor, as a pro-apoptotic member of Bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosi...

Spautin-1
(CAS: 1262888-28-7)

Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM.

BDA 366
(CAS: 1821496-27-8)

BDA-366 is a BCL2-BH4 antagonist(Ki=3.3nM) which suppresses human myeloma growth. BDA-366 induces apoptosis in MM cell lines and primary MM cells by inducing BC...

Mcl1-IN-2
(CAS: 292057-76-2)

Mcl1-IN-2, a hydroxyquinoline derivative, is an Mcl-1 inhibitor.

Mcl1-IN-1
(CAS: 713492-66-1)

Mcl1-IN-1 is a potent Mcl-1-selective inhibitor with IC50 of 2.4 uM, relative to the related Bcl-2 family protein Bcl-xL.

CAS 803712-79-0 Obatoclax mesylate

Obatoclax mesylate
(CAS: 803712-79-0)

Obatoclax mesylate is the mesylate salt of obatoclax, a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and anti...

CAS 923564-51-6 Navitoclax

Navitoclax
(CAS: 923564-51-6)

CAS 852808-04-9 ABT-737

ABT-737
(CAS: 852808-04-9)

S-63845
(CAS: 1799633-27-4)

S-63845 is a selective inhibitor of MCL1 (Ki (MCL1, FP) < 1.2 nM; Kd (MCL1, SPR) = 0.19 nM; Ki (BCL2, FP) > 10.000 1.2 nM; Ki (BCL-XL, FP) > 10.000 1.2 nM). It ...

BDA-366
(CAS: 1909226-00-1)

BDA-366 is a small-molecule antagonist of Bcl2-BH4 domain with high affinity and selectivity for Bcl2-BH4. BDA-366 induces apoptosis in multiple myeloma cells v...

CAS 1426138-42-2 FX1

FX1
(CAS: 1426138-42-2)

FX1 is a selective inhibitor of B cell lymphoma 6 (BCL6) (IC50 = 35 μM in reporter assays), which can disrupt formation of the BCL6 repression complex, reactiva...

Marinopyrrole A
(CAS: 1227962-62-0)

Marinopyrrole A, a new Mcl-1 inhibitor, could influence Mcl-1-Bim interaction and induce the degradation of Mcl-1 proteasomal and also lead to the apoptosis of ...

CAS 866541-93-7 AT-101 acetic acid

AT-101 acetic acid
(CAS: 866541-93-7)

AT101 acetic acid is orally bioavailable solvate of R-(-)-enantiomer of gossypol with potential antineoplastic activity. It is used as the treatment of non Hodg...

WEHI-539 hydrochloride

WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL (IC50= 1.1 nM) with high affinity and selectivity for BCL-XL and potently kills cells by selectively a...

CAS 90141-22-3 AT101

AT101
(CAS: 90141-22-3)

AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM.

(+)-Apogossypol
(CAS: 66389-74-0)

(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins, binding and inhibiting Bcl-2 and Bcl-X(L) with high affinity and induces apoptosis of tumor cell...

Bak BH3

Bak BH3, derived from the BH3 domain of Bak, was found to antagonize the protective effects of microinjected Bcl-xL in a-Fas-treated HeLa cells, whereas a mutan...

Chemical Structure

CAS 90141-22-3 AT101

Quick Inquiry

Verification code

Featured Items