|Description||AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM.|
A-1155463, an effective and selective BCL-XL inhibitor, has been studied to have probable effect in restraining the growth of small cell lung cancer xenograft t...
Mcl1-IN-1 is a potent Mcl-1-selective inhibitor with IC50 of 2.4 uM, relative to the related Bcl-2 family protein Bcl-xL.
TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivat...
Venetoclax is a small-molecule inhibitor that has high selectivity for Bcl-2 (Ki < 0.01 nM in cell-free assays) over Mcl-1. It suppresses anti-apoptotic Bcl-2, ...
WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL (IC50= 1.1 nM) with high affinity and selectivity for BCL-XL and potently kills cells by selectively a...
SMBA 1 is a selelctive and high affinity Bax activator (Ki = 43.3 nM) that binds to the S184 binding pocket and inhibits Bax phosphorylation. SMBA 1 exhibits no...
Muristerone A, a phytoecdysteroid analog of ecdysone, acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals...
Pyridoclax, a pyridine derivative, has been found to be a Mcl-1 inhibitor that could induce apoptosis of cancer cells. IC50: 25 nM(Kd).
A-1210477 is a potent and selective MCL-1 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family member...
FX1 is a selective inhibitor of B cell lymphoma 6 (BCL6) (IC50 = 35 μM in reporter assays), which can disrupt formation of the BCL6 repression complex, reactiva...
Gossypol is an orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cel...
Gambogic acid is a natural product inhibitor of Hsp90.
Navitoclax is an orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antine...
BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.
Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM.
Mcl1-IN-2, a hydroxyquinoline derivative, is an Mcl-1 inhibitor.
Bak BH3, derived from the BH3 domain of Bak, was found to antagonize the protective effects of microinjected Bcl-xL in a-Fas-treated HeLa cells, whereas a mutan...
S-63845 is a selective inhibitor of MCL1 (Ki (MCL1, FP) < 1.2 nM; Kd (MCL1, SPR) = 0.19 nM; Ki (BCL2, FP) > 10.000 1.2 nM; Ki (BCL-XL, FP) > 10.000 1.2 nM). It ...
MIM1 is a small molecule inhibitor of Mcl-1 (IC50= 4.8 uM) by selectively targets the BH3-binding pocket.