AT101 - CAS 90141-22-3
Catalog number: 90141-22-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H30O8·C2H4O2
Molecular Weight:
578.6
COA:
Inquire
Targets:
Bcl-2 Family
Description:
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
AT-101
MSDS:
Inquire
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Bcl-2 Family Products


A-1155463
(CAS: 1235034-55-5)

A-1155463, an effective and selective BCL-XL inhibitor, has been studied to have probable effect in restraining the growth of small cell lung cancer xenograft t...

Mcl1-IN-1
(CAS: 713492-66-1)

Mcl1-IN-1 is a potent Mcl-1-selective inhibitor with IC50 of 2.4 uM, relative to the related Bcl-2 family protein Bcl-xL.

CAS 877877-35-5 TW-37

TW-37
(CAS: 877877-35-5)

TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivat...

CAS 1257044-40-8 venetoclax

venetoclax
(CAS: 1257044-40-8)

Venetoclax is a small-molecule inhibitor that has high selectivity for Bcl-2 (Ki < 0.01 nM in cell-free assays) over Mcl-1. It suppresses anti-apoptotic Bcl-2, ...

WEHI-539 hydrochloride

WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL (IC50= 1.1 nM) with high affinity and selectivity for BCL-XL and potently kills cells by selectively a...

CAS 906440-37-7 SMBA 1

SMBA 1
(CAS: 906440-37-7)

SMBA 1 is a selelctive and high affinity Bax activator (Ki = 43.3 nM) that binds to the S184 binding pocket and inhibits Bax phosphorylation. SMBA 1 exhibits no...

CAS 38778-30-2 Muristerone A

Muristerone A
(CAS: 38778-30-2)

Muristerone A, a phytoecdysteroid analog of ecdysone, acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals...

Pyridoclax
(CAS: 1651890-44-6)

Pyridoclax, a pyridine derivative, has been found to be a Mcl-1 inhibitor that could induce apoptosis of cancer cells. IC50: 25 nM(Kd).

A-1210477
(CAS: 1668553-26-1)

A-1210477 is a potent and selective MCL-1 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family member...

CAS 1426138-42-2 FX1

FX1
(CAS: 1426138-42-2)

FX1 is a selective inhibitor of B cell lymphoma 6 (BCL6) (IC50 = 35 μM in reporter assays), which can disrupt formation of the BCL6 repression complex, reactiva...

CAS 303-45-7 Gossypol

Gossypol
(CAS: 303-45-7)

Gossypol is an orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cel...

CAS 2752-65-0 Gambogic acid

Gambogic acid
(CAS: 2752-65-0)

Gambogic acid is a natural product inhibitor of Hsp90.

CAS 923564-51-6 Navitoclax

Navitoclax
(CAS: 923564-51-6)

Navitoclax is an orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antine...

CAS 331244-89-4 BAM7

BAM7
(CAS: 331244-89-4)

BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.

Spautin-1
(CAS: 1262888-28-7)

Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM.

Mcl1-IN-2
(CAS: 292057-76-2)

Mcl1-IN-2, a hydroxyquinoline derivative, is an Mcl-1 inhibitor.

Bak BH3

Bak BH3, derived from the BH3 domain of Bak, was found to antagonize the protective effects of microinjected Bcl-xL in a-Fas-treated HeLa cells, whereas a mutan...

S-63845
(CAS: 1799633-27-4)

S-63845 is a selective inhibitor of MCL1 (Ki (MCL1, FP) < 1.2 nM; Kd (MCL1, SPR) = 0.19 nM; Ki (BCL2, FP) > 10.000 1.2 nM; Ki (BCL-XL, FP) > 10.000 1.2 nM). It ...

MIM1
(CAS: 509102-00-5)

MIM1 is a small molecule inhibitor of Mcl-1 (IC50= 4.8 uM) by selectively targets the BH3-binding pocket.

CAS 852808-04-9 ABT-737

ABT-737
(CAS: 852808-04-9)

Chemical Structure

CAS 90141-22-3 AT101

Quick Inquiry

Verification code

Featured Items