Astragaloside IV - CAS 84687-43-4
Catalog number:
84687-43-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C41H68O14
Molecular Weight:
784.97
COA:
Inquire
Targets:
Others
Description:
Astragaloside IV has cardiovascular protective effects. It can protect the vascular endothelial cells. Meanwhile, it also have antiinflammatory and anti-virus effects. This is due to its scavenging ability of oxygen free radicals, regulation of mineral homeostasis and antioxidative effects.
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Purity:
98%
Appearance:
White to Off-White Solid
Synonyms:
1H,19H-Cyclopropa[9,10]cyclopenta[a]phenanthrene β-D-Glucopyranoside deriv.; 9,19-Cyclolanostane β-D-Glucopyranoside deriv.; Astragaloside IV; Astrasieversianin XIV; Astraversianin XIV; Cyclosieversioside F; Cyclosiversioside F
Solubility:
Methanol (Slightly, Sonicated), Pyridine (Slightly)
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
cardiovascular protection
Quality Standard:
USP
Shelf Life:
2 month in rt, long time
Quantity:
Grams-Kilos
Boiling Point:
No Data Available
Melting Point:
>278℃ (dec.)
InChIKey:
QMNWISYXSJWHRY-YLNUDOOFSA-N
InChI:
InChI=1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1
Canonical SMILES:
CC1(C(CCC23C1C(CC4C2(C3)CCC5(C4(CC(C5C6(CCC(O6)C(C)(C)O)C)O)C)C)OC7C(C(C(C(O7)CO)O)O)O)OC8C(C(C(CO8)O)O)O)C
1.Effect of Astragaloside IV on Neural Stem Cell Transplantation in Alzheimer's Disease Rat Models.
Haiyan H1, Rensong Y1, Guoqin J1, Xueli Z1, Huaying X1, Yanwu X1. Evid Based Complement Alternat Med. 2016;2016:3106980. doi: 10.1155/2016/3106980. Epub 2016 Feb 23.
Stem cell-based therapy is a promising treatment strategy for neurodegenerative diseases such as Alzheimer's disease (AD). However, the mechanism underlying the maintenance of renewal and replacement capabilities of endogenous progenitor cells or engrafted stem cells in a pathological environment remains elusive. To investigate the effect of astragaloside IV (ASI) on the proliferation and differentiation of the engrafted neural stem cells (NSCs), we cultured NSCs from the hippocampus of E14 rat embryos, treated the cells with ASI, and then transplanted the cells into the hippocampus of rat AD models. In vitro experimentation showed that 10(-5) M ASI induced NSCs to differentiate into β-tubulin III(+) and GFAP(+) cells. NSCs transplantation into rat AD models resulted in improvements in learning and memory, especially in the ASI-treated groups. ASI treatment resulted in an increase in the number of β-tubulin III(+) cells in the hippocampus.
2.Astragaloside IV, a Natural PPARγ Agonist, Reduces Aβ Production in Alzheimer's Disease Through Inhibition of BACE1.
Wang X1, Wang Y1, Hu JP2, Yu S3, Li BK1, Cui Y1, Ren L3, Zhang LD4. Mol Neurobiol. 2016 Mar 29. [Epub ahead of print]
A number of epidemiological studies have established a link between Alzheimer's disease (AD) and diabetes mellitus (DM). So, nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) plays an important role in the treatment of AD. However, current PPARγ-targeting drugs such as thiazolidinediones (TZDs) are associated with undesirable side effects. We identified herbal extract with a small molecular, astragaloside IV (AS-IV), as a selective PPARγ natural agonist in nervous cells by developing a PPAR-PPRE pathway regulatory system. Cultured SH-SY5Y cells transfected with pEGFP-N1-BACE1 were treated with AS-IV for 24 h or AS-IV plus the PPAR-γ antagonist GW9662 in vitro. APP/PS1 mice were intragastrically treated with AS-IV or AS-IV plus the GW9662 every 48 h for 3 months. Immunofluorescence, western blotting, and real-time PCR were used to examine the expression of PPARγ and BACE1. Immunohistochemical staining was performed to analyze the distribution of Aβ plaques in the APP/PS1 mouse brain.
3.Astragaloside IV protects cardiomyocytes from anoxia/reoxygenation injury by upregulating the expression of Hes1 protein.
Huang H1, Lai S1, Wan Q2, Qi W1, Liu J1. Can J Physiol Pharmacol. 2016 May;94(5):542-53. doi: 10.1139/cjpp-2015-0457. Epub 2015 Dec 16.
Astragaloside IV (ASI), a traditional Chinese medicine, is a main active ingredient of Astragalus membranaceus. Many clinical studies have found that ASI protects cardiomyocytes in cardiovascular diseases, but the underlying mechanisms remain obscure. The aim of this study was to investigate the molecular mechanisms responsible for the protective effects of ASI in cardiomyocytes from anoxia/reoxygenation (A/R) injury. According to the previous studies, we hypothesized that the cardioprotective effects of ASI against A/R injury might be associated with Notch1/Hes1 signaling pathway. In this study, neonatal rat primary cardiomyocytes were preconditioned with ASI prior to A/R injury. Our results showed that ASI effectively increased the cell viability, decreased the content of MDA, decreased the activities of CPK and LDH, increased the activities of GSH-Px and SOD, and reduced the reactive oxygen species (ROS) generation and the loss of mitochondrial membrane potential (Δψm).
4.Astragaloside IV prevents high glucose-induced podocyte apoptosis via downregulation of TRPC6.
Yao XM1, Liu YJ1, Wang YM1, Wang H1, Zhu BB1, Liang YP1, Yao WG1, Yu H1, Wang NS2, Zhang XM3, Peng W1. Mol Med Rep. 2016 Apr 22. doi: 10.3892/mmr.2016.5167. [Epub ahead of print]
Diabetic nephropathy (DN) is one of the most important causes of end‑stage renal disease. Astragaloside IV (AS-IV) is a saponin isolated from Astragalus membranaceus, which possesses various pharmacological activities. AS‑IV prevents podocyte apoptosis and ameliorates renal injury in DN; however, few studies have focused on its effects on ion channels. The transient receptor potential channel 6 (TRPC6) is an important Ca2+‑permeable ion channel in podocytes, which is involved in high glucose (HG)-induced podocyte apoptosis. The aim of the present study was to investigate whether AS‑IV prevented HG‑induced podocyte apoptosis via TRPC6. Cultured podocytes were pre‑treated with 10, 20 or 40 µM AS‑IV for 1 h prior to HG exposure for 24 h. Apoptosis, cell viability, expression of TRPC6, nuclear factor of activated T cells (NFAT2) and B‑cell lymphoma 2‑associated X protein (Bax), as well as the intracellular Ca2+ concentration were subsequently analyzed.
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CAS 84687-43-4 Astragaloside IV

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