Astragalin - CAS 480-10-4
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Not Intended for Therapeutic Use. For research use only.
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Astragalin is a flavonoid with anti-inflammatory activity and newly found in persimmon leaves and green tea seeds.
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Astragaline; 3-Glucosylkaempferol; Kaempferol 3-β-D-glucopyranoside
1.The in-capillary DPPH- capillary electrophoresis-the diode array detector combined with reversed-electrode polarity stacking mode for screening and quantifying major antioxidants in Cuscuta chinensis Lam.
Liu J1,2, Tian J1,2, Li J1,2, Azietaku JT1,2, Zhang BL1,2, Gao XM1,2, Chang YX1,2. Electrophoresis. 2016 Mar 9. doi: 10.1002/elps.201500426. [Epub ahead of print]
An in-capillary 2, 2-Diphenyl-1-picrylhydrazyl (DPPH)- capillary electrophoresis-the diode array detector (in-capillary DPPH-CE-DAD) combined with reversed-electrode polarity stacking mode has been developed to screen and quantify the active antioxidant components of Cuscuta chinensis Lam. The operation parameters were optimized with regard to the pH and concentration of buffer solution, sodium dodecyl sulfate (SDS), β-Cyclodextrins(β-CD), organic modifier, as well as separation voltage and temperature. Six antioxidants including chlorogenic acid, p-coumaric acid, rutin, hyperin, isoquercitrin and astragalin were screened and the total antioxidant activity of the complex matrix was successfully evaluated based on the decreased peak area of DPPH by the established DPPH-CE-DAD method. Sensitivity was enhanced under reversed-electrode polarity stacking mode and 10-31-fold of magnitude improvement in detection sensitivity for each analyte was attained.
2.Chemical constituents isolated from Zygophyllum melongena Bunge growing in Mongolia.
Ganbaatar C1, Gruner M1, Tunsag J1,2, Batsuren D2, Ganpurev B3, Chuluunnyam L2, Sodbayar B4, Schmidt AW1, Knölker HJ1. Nat Prod Res. 2016 Jan 11:1-4. [Epub ahead of print]
We report the first investigation of the chemical constituents of Zygophyllum melongena Bunge, a species growing in Mongolia. The quinovic acid glycosides 3-O-(β-D-glucopyranosyl)quinovic acid and 3-O-(β-D-glucopyranosyl)quinovic acid (28→1)-(β-D-glucopyranosyl) ester were identified in the chloroform fraction along with the flavonoid glycoside astragalin. The n-butanol fraction contained (+)-D-pinitol as the major component, a cyclitol with anti-diabetic properties. The structures of the isolated natural products were confirmed using ESI-MS and NMR spectroscopy (1H, 13C, COSY, HSQC, HMBC, NOESY and ROESY). This is the first report of the isolation of (+)-D-pinitol from the genus Zygophyllum.
3.Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart.
Qu D1, Han J2, Ren H2, Yang W3, Zhang X1, Zheng Q2, Wang D1. Oxid Med Cell Longev. 2016;2016:8194690. doi: 10.1155/2016/8194690. Epub 2015 Dec 16.
This study aims to evaluate the cardioprotective effects of astragalin against myocardial ischemia/reperfusion (I/R) injury in isolated rat heart. The cardioprotective effects of astragalin on myocardial I/R injury were investigated on Langendorff apparatus. Adult male Sprague-Dawley rats were randomly divided into five groups. The results showed that astragalin pretreatment improved myocardial function. Compared with I/R group, lactate dehydrogenase (LDH) and creatine kinase (CK) activities in coronary flow decreased in astragalin pretreatment groups, whereas superoxide dismutase (SOD) activity and glutathione/glutathione disulfide (GSH/GSSG) ratio significantly increased. The levels of malondialdehyde (MDA), intracellular reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) decreased in astragalin-treated groups. The infarct size (IS) and apoptosis rate in hearts from astragalin-treated groups were lower than those in hearts from the I/R group.
4.Flavonoids of Calligonum polygonoides and their cytotoxicity.
Ahmed H1, Moawad A1, Owis A1, AbouZid S1, Ahmed O2. Pharm Biol. 2016 Feb 28:1-8. [Epub ahead of print]
Context Calligonum polygonoides L. subsp. comosum L' Hér. (Polygonaceae), locally known as "arta", is a slow-growing small leafless desert shrub. Objective Isolation, structure elucidation and evaluation of cytotoxic activity of flavonoids from C. polygonoides aerial parts. Materials and methods Flavonoids in the hydroalcoholic extract of the of C. polygonoides were isolated and purified using column chromatography and preparative HPLC. The structures of the isolated flavonoids were elucidated on the basis of spectroscopic data including 2D NMR techniques. The cytotoxic activity of the isolated flavonoids (6.25, 25, 50 and 100 μg/mL) was evaluated against liver HepG2 and breast MCF-7 cancer cell lines using sulphorhodamine-B assay. Results A new flavonoid, kaempferol-3-O-β-D-(6″-n-butyl glucuronide) (1), and 13 known flavonoids, quercetin 3-O-β-D-(6″-n-butyl glucuronide) (2), kaempferol-3-O-β-D-(6″-methyl glucuronide) (3), quercetin-3-O-β-D-(6″-methyl glucuronide) (4), quercetin-3-O-glucuronide (5), kaempferol-3-O-glucuronide (6), quercetin-3-O-α-rhamnopyranoside (7), astragalin (8), quercetin-3-O-glucopyranoside (9), taxifolin (10), (+)-catechin (11), dehydrodicatechin A (12), quercetin (13), and kaempferol (14), were isolated from the aerial parts of C.
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CAS 480-10-4 Astragalin

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