AST-1306 - CAS 897383-62-9
Catalog number:
897383-62-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H18ClFN4O2
Molecular Weight:
448.88
COA:
Inquire
Targets:
EGFR
Description:
AST-1306 functions as an irreversible inhibitor, most likely through covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and ErbB2, respectively. It inactivated pathways downstream of these receptors and thereby inhibited the proliferation of a panel of cancer cell lines. It blocks phosphorylation of EGFR and also prevents downstream pathways. It also dose-dependently inhibits EGF-induced EGFR phosphorylation in the A549 cancer cell line.
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Purity:
>98%
MSDS:
Inquire
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CAS 897383-62-9 AST-1306

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