Asenapine Maleate - CAS 85650-56-2
Catalog number:
B0084-007055
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H20ClNO5
Molecular Weight:
401.843
COA:
Inquire
Targets:
5-HT Receptor
Description:
Asenapine Maleate is a 5-HT receptor antagonist used for the treatment of acute schizophrenia and bipolar mania. It is a second-generation (atypical) antipsychotic agent.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-007055 1 g $175 In stock
Bulk Inquiry
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
5-HT receptor antagonist, acute schizophrenia, bipolar mania
Appearance:
White Solid
Synonyms:
Saphris
MSDS:
Inquire
Application:
the treatment of acute schizophrenia and bipolar mania
Melting Point:
141-143°C
InChIKey:
GMDCDXMAFMEDAG-CHHFXETESA-N
InChI:
InChI=1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1
Canonical SMILES:
CN1CC2C(C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24.C(=CC(=O)O)C(=O)O
1.Asenapine for bipolar disorder.
Scheidemantel T1, Korobkova I2, Rej S3, Sajatovic M4. Neuropsychiatr Dis Treat. 2015 Dec 4;11:3007-17. doi: 10.2147/NDT.S78043. eCollection 2015.
Asenapine (Saphris(®)) is an atypical antipsychotic drug which has been approved by the US Food and Drug Administration for the treatment of schizophrenia in adults, as well as the treatment of acute manic or mixed episodes of bipolar I in both adult and pediatric populations. Asenapine is a tetracyclic drug with antidopaminergic and antiserotonergic activity with a unique sublingual route of administration. In this review, we examine and summarize the available literature on the safety, efficacy, and tolerability of asenapine in the treatment of bipolar disorder (BD). Data from randomized, double-blind trials comparing asenapine to placebo or olanzapine in the treatment of acute manic or mixed episodes showed asenapine to be an effective monotherapy treatment in clinical settings; asenapine outperformed placebo and showed noninferior performance to olanzapine based on improvement in the Young Mania Rating Scale scores. There are limited data available on the use of asenapine in the treatment of depressive symptoms of BD, or in the maintenance phase of BD.
2.Atypical Antipsychotics in the Treatment of Acute Bipolar Depression with Mixed Features: A Systematic Review and Exploratory Meta-Analysis of Placebo-Controlled Clinical Trials.
Fornaro M1, Stubbs B2,3, De Berardis D4, Perna G5, Valchera A6, Veronese N7, Solmi M8, Ganança L9,10. Int J Mol Sci. 2016 Feb 16;17(2). pii: E241. doi: 10.3390/ijms17020241.
Evidence supporting the use of second generation antipsychotics (SGAs) in the treatment of acute depression with mixed features (MFs) associated with bipolar disorder (BD) is scarce and equivocal. Therefore, we conducted a systematic review and preliminary meta-analysis investigating SGAs in the treatment of acute BD depression with MFs. Two authors independently searched major electronic databases from 1990 until September 2015 for randomized (placebo-) controlled trials (RCTs) or open-label clinical trials investigating the efficacy of SGAs in the treatment of acute bipolar depression with MFs. A random-effect meta-analysis calculating the standardized mean difference (SMD) between SGA and placebo for the mean baseline to endpoint change in depression as well as manic symptoms score was computed based on 95% confidence intervals (CI). Six RCTs and one open-label placebo-controlled studies (including post-hoc reports) representing 1023 patients were included.
3.The geriatric mania asenapine study (GeMS).
Barak Y1, Finkelstein I2, Pridan S3. Arch Gerontol Geriatr. 2016 May-Jun;64:111-4. doi: 10.1016/j.archger.2016.01.012. Epub 2016 Jan 25.
RATIONALE: Population aging results in growing numbers of psychiatric disorders among older patients. Yet, there is a paucity of studies on elderly mania.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related 5-HT Receptor Products


CAS 222318-55-0 (4E)-SUN9221

(4E)-SUN9221
(CAS: 222318-55-0)

A potent dual antagonist of α1-adrenergic receptor and 5-HT2 receptor

CAS 839713-36-9 Nelotanserin

Nelotanserin
(CAS: 839713-36-9)

Nelotanser is Serotonin 2A receptor inverse agonist. In Aug 2016, Axovant Sciences initiated a phase-II clinical trial in Lewy body disease in USA.

CAS 192927-92-7 LY310762

LY310762
(CAS: 192927-92-7)

LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from...

CAS 146939-27-7 Ziprasidone

Ziprasidone
(CAS: 146939-27-7)

Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist like other atypical antipsychotic agents. Ziprasidone targets dopamine neurotransmis...

CAS 119193-37-2 LY 278584

LY 278584
(CAS: 119193-37-2)

LY 278584 is a 5-HT3-receptor antagonist and no detailed information has been published yet.

CAS 24276-84-4 Ferulic acid sodium

Ferulic acid sodium
(CAS: 24276-84-4)

Ferulic acid sodium is one of the most abundant phenolic acids ubiquitously existing in plants. Free ferulic acid is a good antioxidant since it forms a resonan...

CAS 123040-16-4 Azasetron hydrochloride

Azasetron hydrochloride
(CAS: 123040-16-4)

Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.

CAS 467458-02-2 Lu AE58054 HCl salt

Lu AE58054 HCl salt
(CAS: 467458-02-2)

Lu AE58054 hydrochloride is an in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT(6)R antagonist with a Ki value of 0.83 nM.

CAS 554403-49-5 WAY181187

WAY181187
(CAS: 554403-49-5)

WAY181187 is a potent and selective 5-HT6 receptor full agonist. It possesses high affinity binding at the human 5-HT6 receptor and profile as full receptor ago...

BRL 15572
(CAS: 734517-40-9)

BRL-15,572 is selective 5-HT1D antagonist with around 60x selectivity over other related receptors. It is a useful tool for the differentiation between human 5-...

CAS 367514-88-3 Lurasidone hydrochloride

Lurasidone hydrochloride
(CAS: 367514-88-3)

Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and ...

CAS 1331782-27-4 PF-04995274

PF-04995274
(CAS: 1331782-27-4)

PF-04995274 is a 5-HT4 receptor partial agonist with Ki = 0.15 - 0.46 nM for 5-HT4 isoforms a, b, d and e, developed for the treatment of Alzheimer's disease (A...

CAS 1038988-11-2 5HT6-ligand-1

5HT6-ligand-1
(CAS: 1038988-11-2)

5HT6-ligand-1 is a potent 5-HT6 receptor ligand (Ki= 1.43 nM).

CAS 916918-84-8 Ansofaxine hydrochloride

Ansofaxine hydrochloride
(CAS: 916918-84-8)

Ansofaxine hydrochloride is a triple reuptake inhibitor of serotonin (IC50= 723 nM), dopamine (IC50= 491 nM) and norepinephrine reuptake (IC50= 763 nM).

CAS 5189-11-7 Pizotifen Malate

Pizotifen Malate
(CAS: 5189-11-7)

Pizotifen Malate is a benzocycloheptane based agent used for recurrent migraine headaches.

LY 344864 racemate
(CAS: 186543-64-6)

LY 344864 racemate is a 5-HT1F receptor agonist.

Ziprasidone-d8
(CAS: 1126745-58-1)

A labelled form of Ziprasidone which is an antagonist of both 5-HT and dopamine receptor and it has been studied to show effective antipsychotic activity.

CAS 145202-66-0 Rizatriptan Benzoate

Rizatriptan Benzoate
(CAS: 145202-66-0)

Rizatriptan Benzoate is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.

CAS 111974-69-7 Quetiapine

Quetiapine
(CAS: 111974-69-7)

Quetiapine, an thiazepin-analogue of Clozapine, could be effective in the treatment for schizophrenia and major depressive disorder for behaving as a 5HT-2 and ...

CAS 83366-66-9 NEFAZODONE

NEFAZODONE
(CAS: 83366-66-9)

Nefazodone is a selective serotonin 5-HT2 receptor antagonist. It is an antidepressant under the development of Bristol-Myers Squibb. Its sale was discontinued ...

Chemical Structure

CAS 85650-56-2 Asenapine Maleate

Quick Inquiry

Verification code

Featured Items