α-Asarone - CAS 2883-98-9
Catalog number: 2883-98-9
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Molecular Formula:
C12H16O3
Molecular Weight:
208.25
COA:
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Chemical Family:
Phenylpropanoids
Description:
α-Asarone is a natural phenylpropanoid compound found in
the seeds of Daucus carota. As a volatile fragrance oil, it is used in killing pests and bacteria, which means that the compound shows insecticidal activity.
Purity:
>95%
Appearance:
Powder
Synonyms:
Trans-Isoasarone;
MSDS:
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Application:
insecticidal
Quality Standard:
Enterprise Standard
Quantity:
Grams-Kilograms
Density:
1.0±0.1 g/cm3
1.Anticonvulsant activities of α-asaronol ((E)-3'-hydroxyasarone), an active constituent derived from α-asarone.
He X;Bai Y;Zeng M;Zhao Z;Zhang Q;Xu N;Qin F;Wei X;Zhao M;Wu N;Li Z;Zhang Y;Fan TP;Zheng X Pharmacol Rep. 2018 Feb;70(1):69-74. doi: 10.1016/j.pharep.2017.08.004. Epub 2017 Aug 31.
BACKGROUND: ;Epilepsy is one of chronic neurological disorders that affects 0.5-1.0% of the world's population during their lifetime. There is a still significant need to develop novel anticonvulsant drugs that possess superior efficacy, broad spectrum of activities and good safety profile.;METHODS: ;α-Asaronol and two current antiseizure drugs (α-asarone and carbamazepine (CBZ)) were assessed by in vivo anticonvulsant screening with the three most employed standard animal seizure models, including maximal electroshock seizure (MES), subcutaneous injection-pentylenetetrazole (PTZ)-induced seizures and 3-mercaptopropionic acid (3-MP)-induced seizures in mice. Considering drug safety evaluation, acute neurotoxicity was assessed with minimal motor impairment screening determined in the rotarod test, and acute toxicity was also detected in mice.;RESULTS: ;In our results, α-asaronol displayed a broad spectrum of anticonvulsant activity (ACA) and showed better protective indexes (PI = 11.11 in MES, PI = 8.68 in PTZ) and lower acute toxicity (LD;50; = 2940 mg/kg) than its metabolic parent compound (α-asarone). Additionally, α-asaronol displayed a prominent anticonvulsant profile with ED;50; values of 62.
2.Development of a selective and sensitive LC-MS/MS method for the quantification of α-asarone in mouse plasma and its application to pharmacokinetic studies.
Ramalingam P;Ganesan P;Choi DK;Ko YT J Pharm Biomed Anal. 2018 Mar 20;151:284-290. doi: 10.1016/j.jpba.2018.01.024.
A simple, sensitive and selective liquid chromatography-tandem mass spectrometric method was developed and validated for the quantification of α-asarone in mouse plasma with its application to pharmacokinetic studies. An electrospray ionization (ESI) with multiple reaction monitoring (MRM) mode was used to monitor the precursor-product ion transitions of 209.1 > 193.9 m/z for α-asarone and 157.8 > 114.0 m/z for allantoin. Chromatographic separation was acquired on a Sepax BR-C18 (5 μm, 120 Å 1.0 × 100 mm) column with an isocratic mobile phase consisting of methanol and 0.1% formic acid (80:20, v/v). The developed bioanalytical method was successfully validated according to the United States Food and Drug Administration (US FDA) guidelines for linearity, selectivity, accuracy, precision, recovery, matrix effect, and stability. The validated method was successfully applied to a pharmacokinetics study of α-asarone along with a combination of pharmacokinetic techniques, including small-volume serial blood sampling in mice, reducing drug doses and the number of animals used, using a simple protein precipitation method and less solvent consumption will enable its use in further bioequivalence studies.
3.The involvement of neuronal nitric oxide synthase in antiepileptic action of alpha-asarone on pentylenetetrazol molding rats.
Su J;Zhu W;Liu J;Yin J;Qin W;Jiang C Biomed Mater Eng. 2014;24(6):3645-55. doi: 10.3233/BME-141192.
The aim of the present study was to research the role of nitric oxide (NO) as a mediator of alpha (α)-asarone effect at the pentylenetetrazol (PTZ)-induced epileptiform discharge in rat. α-Asarone that was injected intraperitoneally twenty minutes before PTZ injection suppressed the clonic discharge effectively and the significant actions lasted for 30 min with no change of clonic amplitude. Administration of α-asarone did not influence interictal discharge. Four kinds of NO regulators were administered, including non-selective NG-nitro-L-arginine methyl ester (L-NAME), selective neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7-NI), inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AG) and NO substrate, L-arginine (ARG) and their influence on the actions of α-asarone were studied, and all of the regulators were administered fifteen minutes before α-asarone injection. L-NAME and 7-NI reversed the anticlonic activity of α-asarone, and a significant increase of clonic activity was induced by L-NAME later in L-NAME +.α-asarone + PTZ group. There were no significant differences between AG + α-asarone + PTZ and α-asarone + PTZ group. L-ARG played a dual role in this study.
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CAS 2883-98-9 α-Asarone

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