|Description||Arzoxifene, also known as LY353381, a synthetic aromatic derivative with anti-estrogenic properties, displays greater bioavailability and higher anti-estrogenic potency in the breast than another selective estrogen receptor modulators (SERMs),raloxifene.|
|Related CAS||182133-25-1(free base); 182133-27-3(HCl salt)|
|Synonyms||2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol; 4'F-DMA; 182133-27-3 (hydrochloride salt); arzoxifene; LY 353381; LY-353381; LY353381|
|Current Developer||Eli Lilly|
Panomifene is an Estrogen receptor antagonist under the development of Egis Pharmaceuticals. Phase II clinical trials for the treatment of breast cancer was dis...
Estrone is one of the three naturally occurring estrogens, the others being estradiol and estriol. Estrone is synthesized from androstenedione by the aromatase ...
AZD9496 maleate is potent downregulator of estrogen receptor in breast carcinoma cells and also antagonise ERα with good oral pharmacokinetic properties. It is ...
Nafoxidine HCl is the hydrochloride salt of nafoxidine. Nafoxidine, structurally related to Tamoxifen, is a non-steroidal partial estrogen antagonist.
Endoxifen E-isomer hydrochloride
The hydrochloride salt form of E-isomer of Endoxifen which is a significant metamolite of Tamoxifen, could be a regulator of estrogen receptor and could be effe...
Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.
Phenethipylone is a selective estrogen receptor modulator. It is a raloxifene analog.
Estradiol valerate is a synthetic ester, specifically the 17-pentanoyl ester, of the natural estrogen, 17β-estradiol. It was introduced in the 1950s, and a...
Elacestrant, also referred to RAD1901, is a selective and orally available estrogen receptor (ERR) degrader (IC50= 48 and 870 nM for ERα and ERβ, respectively) ...
Diarylpropionitrile, also called as DPN, is a selective agonist of estrogen receptor β (ERβ) with a 70-fold higher relative binding affinity for ERβ(18%) versus...
Toremifene citrate is a selective estrogen receptor modulator (SERM) that binds to estrogen receptors to inhibit the estrogen activity.
A selective agonist of estrogen receptor α
Genistin is a derivative of Genistein, which is a PTK inhibitor. Genistin acts as a selective estrogen receptor modulator (SERM). It increases growth of breast ...
CHF-4227 is a selective estrogen receptor modulator, binds with high affinity to the human estrogen receptor-alpha and -beta (dissociation constant K(i) = 0.017...
Elacestrant S enantiomer dihydrochloride is an low activity enantiomer of elacestrant dihydrochloride. Elacestrant, also referred to RAD1901, is a selective and...
ZB716 is a steroidal and orally bioactive selective estrogen receptor downregulator (SERD) with antiestrogenic activity. In both tamoxifen-naive and tamoxifen-r...
Ethinyl Estradiol is a derivative of 17β-estradiol (E2), the major endogenous estrogen in humans. EE2 is an orally bioactive estrogen used in many formulations ...
AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. AZD9496 can induce ERα degradation in breast cancer cell l...
Enclomiphene citrateis a non-steroidal estrogen receptor antagonist. It can be used for secondary hypogonadism in overweight men wishing to restore normal testi...
Bazedoxifene acetate, also called as TSE424 or WAY-140424, with antiosteoporotic it is a selective nonsteroidal estrogen receptor modulator (SERM) (ERα: IC50= 2...