Arzoxifene - CAS 182133-25-1
Catalog number: 182133-25-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C28H29NO4S
Molecular Weight:
475.60
COA:
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Targets:
Estrogen Receptor/ERR
Description:
Arzoxifene, also known as LY353381, a synthetic aromatic derivative with anti-estrogenic properties, displays greater bioavailability and higher anti-estrogenic potency in the breast than another selective estrogen receptor modulators (SERMs),raloxifene.
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Purity:
>98%
Related CAS:
182133-25-1(free base); 182133-27-3(HCl salt)
Appearance:
Solid powder
Synonyms:
2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol; 4'F-DMA; 182133-27-3 (hydrochloride salt); arzoxifene; LY 353381; LY-353381; LY353381
MSDS:
Inquire
InChIKey:
MCGDSOGUHLTADD-UHFFFAOYSA-N
InChI:
InChI=1S/C28H29NO4S/c1-31-22-8-5-20(6-9-22)28-27(25-14-7-21(30)19-26(25)34-28)33-24-12-10-23(11-13-24)32-18-17-29-15-3-2-4-16-29/h5-14,19,30H,2-4,15-18H2,1H3
Canonical SMILES:
COC1=CC=C(C=C1)C2=C(C3=C(S2)C=C(C=C3)O)OC4=CC=C(C=C4)OCCN5CCCCC5
Current Developer:
Eli Lilly
1.Correlation between 25-hydroxyvitamin D levels and latitude in Brazilian postmenopausal women: from the Arzoxifene Generations Trial.
Arantes HP1, Kulak CA, Fernandes CE, Zerbini C, Bandeira F, Barbosa IC, Brenol JC, Russo LA, Borba VC, Chiang AY, Bilezikian JP, Lazaretti-Castro M. Osteoporos Int. 2013 Oct;24(10):2707-12. doi: 10.1007/s00198-013-2366-x. Epub 2013 Apr 30.
SUMMARY: We investigated vitamin D status in Brazilian cities located at different latitudes. Insufficiency (<50 nmol/L) was common (17 %), even in those living in a tropical climate. Vitamin D insufficiency increased as a function of latitude. Mean 25-hydroxyvitamin D (25(OH)D) levels in each site and latitude correlation were very high (r = -0.88; p=0.02). [corrected].
2.Incidence of vertebral fractures in calcium and vitamin D-supplemented postmenopausal Brazilian women with osteopenia or osteoporosis: data from Arzoxifene Generations Trial.
Arantes HP1, Gimeno SG2, Chiang AY3, Bilezikian JP4, Lazaretti-Castro M1. Arch Endocrinol Metab. 2016 Feb;60(1):54-9. doi: 10.1590/2359-3997000000141.
Objective Vertebral fracture is the most common osteoporotic fracture, affecting quality of life and increasing mortality. Epidemiological data on incidence of vertebral fracture are scarce in Brazil and throughout Latin America. Our aim was to determine vertebral fracture incidence and risk factors in a female Brazilian population. Subjects and methods Postmenopausal women with low bone mass were studied from the Brazilian placebo group of Arzoxifene Generations Trial (n = 974), followed for up to 5 years. The primary endpoint was new vertebral fractures, detected by X-Ray. Experimental design defined two strata: A. Osteoporosis or previous vertebral fracture with osteopenia; B. Osteopenia without previous fracture. Previous fracture, T-score, ionized calcium, alkaline phosphatase, creatinine and glucose were analyzed at baseline. Crude and adjusted incidence rates of vertebral fractures were estimated and Poisson regression model was used.
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