ARRY 403 - CAS 1304015-76-6
Catalog number: 1304015-76-6
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C20H18N6O3S2
Molecular Weight:
454.53
COA:
Inquire
Targets:
Glucokinase
Description:
ARRY-403 is an orally available Glucokinase stimulants originated by Array BioPharma. ARRY-403 activates human glucokinase in vitro with EC50 of 79 nM at 5 mM glucose and Vmax = 134% compared to the no activator control. It exhibits good in vitro drug-like properties and selectivity against broad panels of receptors and enzymes. But,treatment for Type 2 diabetes mellitus was discontinued.
Purity:
98%
Appearance:
Powder
Synonyms:
AMG151;(1S)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Type 2 diabetes mellitus
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Canonical SMILES:
O[C@@H](C1=NSC(NC2=NC=C(SC3=NC=CC=C3)C=C2OC4=CC=CN=C4C)=N1)CO
Current Developer:
Originator Array BioPharma
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CAS 1304015-76-6 ARRY 403

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