ARQ-092 - CAS 1313881-70-7
Catalog number:
1313881-70-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H24N6
Molecular Weight:
432.53
COA:
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Targets:
Akt | Ser/Thr Protease
Description:
ARQ-092, also called as Miransertib, is an oral activie, potent and selective AKT inhibitor with IC50= 5.0 nM against AKT1, 4.5 nM against AKT2 and 16 nM against AKT3. ARQ-092 inhibits the PI3K/AKT signaling pathway due to inhibition of the activity of AKT in a non-ATP competitive manner. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis.
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Purity:
>98%
Related CAS:
1313881-70-7 (free); 1313883-00-9 (HCl); 1817727-87-9 (3HCl)
Appearance:
Solid powder
Synonyms:
3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine; ARQ092; ARQ-092; ARQ 092; Miransertib
MSDS:
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InChIKey:
HNFMVVHMKGFCMB-UHFFFAOYSA-N
InChI:
1S/C27H24N6/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2,(H2,28,30)
Canonical SMILES:
NC1=NC=CC=C1C2=NC3=CC=C(C4=CC=CC=C4)N=C3N2C5=CC=C(C6(N)CCC6)C=C5
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