Arecoline hydrobromide - CAS 300-08-3
Catalog number:
300-08-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C8H13NO2.HBr
Molecular Weight:
236.11
COA:
Inquire
Targets:
mAChR
Description:
Arecoline is a muscarinic acetylcholine receptor agonist.
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Purity:
>98%
Synonyms:
Arecoline hydrobromide
MSDS:
Inquire
1.Evaluation of arecoline hydrobromide toxicity after a 14-day repeated oral administration in Wistar rats.
Wei X1, Zhang J1, Niu J1, Zhou X1, Li J1, Li B1. PLoS One. 2015 Apr 16;10(4):e0120165. doi: 10.1371/journal.pone.0120165. eCollection 2015.
A subchronic toxicity test was conducted in rats on the basis of a previous acute toxicity test to evaluate the safety of arecoline hydrobromide (Ah), to systematically study its pharmacological effects and to provide experimental support for a safe clinical dose. Eighty rats were randomly divided into four groups: a high-dose group (1000 mg/kg), medium-dose group (200 mg/kg), low-dose group (100mg/kg) and blank control group. The doses were administered daily via gastric lavage for 14 consecutive days. There were no significant differences in the low-dose Ah group compared to the control group (P>0.05) with regard to body weight, organ coefficients, hematological parameters and histopathological changes. The high-dose of Ah influenced some of these parameters, which requires further study. The results of this study indicated that a long-term, continuous high dose of Ah was toxic. However, it is safe to use Ah according to the clinically recommended dosing parameters.
2.Echinococcus granulosus and other intestinal helminths in semi-stray dogs in Tunisia: infection and re-infection rates.
Lahmar S1, Sarciron ME, Rouiss M, Mensi M. Tunis Med. 2008 Jul;86(7):657-64.
OBJECTIVE: Assessing the baseline prevalence and the re-infection rate of E. granulosus and other cestodes in dogs is important for a control program based on regular dog dosing treatment with praziquantel mainly to young rural dogs.
3.Determination and pharmacokinetic studies of arecoline in dog plasma by liquid chromatography-tandem mass spectrometry.
Li B1, Zhou XZ1, Li JY1, Yang YJ1, Niu JR1, Wei XJ1, Liu XW1, Li JS1, Zhang JY2. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 15;969:12-8. doi: 10.1016/j.jchromb.2014.07.043. Epub 2014 Aug 8.
A rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of arecoline concentration in dog plasma. Plasma sample was prepared by protein precipitation using n-hexane (containing 1% isoamyl alcohol) with β-pinene as an internal standard. Chromatographic separation was achieved on an Agilent C18 column (4.6×75mm, 3.5μm) using methanol: 5mM ammonium acetate as the mobile phase with isocratic elution. Mass detection was carried out using positive electrospray ionization in multiple reaction monitoring mode. The calibration curve for arecoline was linear over a concentration range of 2-500ng/mL. The intra-day and inter-day accuracy and precision were within the acceptable limits of ±10% at all concentrations. In summary, the LC-MS/MS method described herein was fully validated and successfully applied to the pharmacokinetic study of arecoline hydrobromide tablets in dogs after oral administration.
4.Frequency- and state-dependent blockade of human ether-a-go-go-related gene K+ channel by arecoline hydrobromide.
Zhao XY1, Liu YQ, Fu YC, Xu B, Gao JL, Zheng XQ, Lin M, Chen MY, Li Y. Chin Med J (Engl). 2012 Mar;125(6):1068-75.
BACKGROUND: The rapidly activating delayed rectifier potassium current (I(Kr)), whose pore-forming alpha subunit is encoded by the human ether-a-go-go-related gene (hERG), is a key contributor to the third phase of action potential repolarization. The aim of this study was to investigate the effect and mechanism of arecoline hydrobromide induced inhibition of hERG K(+) current (I(hERG)).
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CAS 300-08-3 Arecoline hydrobromide

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