Arctiin - CAS 20362-31-6
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Not Intended for Therapeutic Use. For research use only.
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Arctiin has shown to be a suppressor of cyclin D1 protein expression in multiple types of human tumor cells, such as osteosarcoma, lung, colorectal, cervical, breast, melanoma, and prostate cancer. Arctiin has also shown antiviral activity against influenza A when used along or in combination with oseltamivir.
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Arctii; NSC 315527; Arctigenin-4-glucoside
1. An update on bioactive plant lignans
Muhammad Saleem, Hyoung Ja Kim, Muhammad Shaiq Ali and Yong Sup Lee*. Nat. Prod. Rep. , 2005, 22 , 696–716
Although lignans have been reported to possess antitumor activity in various cancer cells, their anticancer effects in human prostate cancer have rarely been established. Chueh et al. examined the effect of 24 on growth regulation in prostate cancer PC-3 cells. Treatment of PC-3 cells with 24 decreased the cell number in a concentration- and time-dependent manner. Arctiin 24 preferentially induced cell detachment, but did not have antiproliferation or cytotoxic effects in PC-3 cells. This investigation revealed that 24 significantly induces cell detachment and decreases the cell numbers by the up-regulation of MUC-1 mRNA and protein in PC-3 cells.
2. Investigation of interaction between bovine serum albumin and drugs by fluorescence spectrometry
Yuping Bai, Shuo Sun, Hanqi Zhang and Tianqi Zhao*. Anal. Methods, 2013, 5, 7036–7041
The acylation of MPA on the Ag+ activated thiol resin was completed, and unacylated MPA was removed by the procedure mentioned above. Then, 1.5 mL of triethanolamine was injected into the centrifuge tube to perform its binding on the activated surface for 40 min and PBS buffer was added into the centrifuge tube to wash off unbound triethanolamine. The standard solution of arctiin or liquiritin was added into the centrifuge tube. After 20 min, the supernatant was analyzed by fluorescence spectrometry to obtain the concentrations of arctiin and liquiritin.
3. Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/b-catenin pathway
Shouyue Zhang, Jie Li, Lulu Cai*. Mol. BioSyst., 2015, 11, 2878—2884
Fructus arctii is the dried ripe fruit of Arctium lappa L., also called “Niu bang zi” in China. Fructus arctii is a well-known Chinese Tradition Medicine, which mainly contains dibenzylbutyrolactone lignans of arctiin and Arctigenin (ARG, see Fig. 1). Many pharma cological studies revealed that Arctigenin possessed many important bioactivities, including anti-proliferation, anti-virus anti-inflammation, neuroprotection, inducing apoptosis and ER stress regulation, etc. Recently, Li et al. reported that Arctigenin exhibited neuroprotective activity via reducing surplus ROS prduction and down-regulated the mitochondrial membrane potential. Hsieh et al. revealed that Arctigenin changed the expression level of Bcl-2 by p38/ATF-2-mediated histone methyltion, resulting the increase of superoxide anions and hydrogen peroxide. Moreover, the Arctigenin induced mitochondria caspase-independent apoptosis of MDA-MB-231 cells through the regulation of the NOX1 and p38-MAPK pathway. Wang et al. combined the Arctigenin, curcumin and epigallocatechin gallate (EGCG) to treat the human prostate cancer LNCaP cells and breast cancer MCF-7 cells, results showed that the combination significantly increased the ratio of Bax to Bcl-2 proteins, decreased the NFkB activation, PI3K/Akt and Stat3 pathways and cell migration both in vitro and in vivo. Most recently, themechanistic studies of Arctigenin towards human hepatocellular carcinoma (HCC) HepG2 and SMMC7721 cells suggested that Arctigenin could induce apoptosis in HCC cells but not in normal hepatic cells, and its apoptotic effect is associated with the mitochondria mediated pathway and depends on the decrease of the mitochondrial out membrane potential, up-regulation of Bax, down-regulation of Bcl-2, a release of cytochrome c, caspase-9 and caspase-3 activation and a cleavage of poly (ADP-ribose) polymerase. Moreover, the increased expression of Fas/FasL, TNF-a and the activation of caspase-8 showed that the death receptor related apoptotic pathway was also involved in this process.
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CAS 20362-31-6 Arctiin

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