Arbutin - CAS 497-76-7
Catalog number: B0084-292329
Category: Inhibitor
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Molecular Formula:
C12H16O7
Molecular Weight:
272.253
COA:
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Targets:
Others
Description:
Arbutin is a glycosylated hydroquinone extracted from bearberry plant. Arbutin acts as an inhibitor of tyrosinase, and is used as a skin-lightening agent for the prevention of melanin formation in skin conditions.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-292329 50 g $179 In stock
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Brife Description:
tyrosinase inhibitor
Purity:
≥ 98%
Appearance:
White Solid
Synonyms:
BRN 0089673; CCRIS 9273; HSDB 7661; NSC 4036; BRN0089673; CCRIS9273; HSDB7661; NSC 4036; BRN-0089673; CCRIS-9273; HSDB-7661; NSC-4036; Uvasol; 4-Hydroxyphenyl beta-D-glucopyranoside; Ursin; Beta-Arbutin
MSDS:
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Application:
skin-lightening agent
Melting Point:
198-201°C
InChIKey:
BJRNKVDFDLYUGJ-RMPHRYRLSA-N
InChI:
InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1
Canonical SMILES:
C1=CC(=CC=C1O)OC2C(C(C(C(O2)CO)O)O)O
1.Arbutin encapsulated micelles improved transdermal delivery and suppression of cellular melanin production.
Liang K1, Xu K1, Bessarab D2, Obaje J2, Xu C3,4. BMC Res Notes. 2016 Apr 30;9(1):254. doi: 10.1186/s13104-016-2047-x.
BACKGROUND: Hyperpigmentation is a skin disorder characterized by elevated production of melanin. Current treatment approaches mainly rely on the application of skin lightening chemicals, most of which have safety issues. Efficacy of delivery of the active ingredients to the target organ has also been a challenge. Transdermal based drug delivery platform has been shown to improve drug bioavailability, avoiding the hepatic first pass metabolism, decrease gastrointestinal side effects, and eventually enhance patient compliance.
2.The Efficacy of Umbelliferone, Arbutin, and N-Acetylcysteine to Prevent Microbial Colonization and Biofilm Development on Urinary Catheter Surface: Results from a Preliminary Study.
Cai T1, Gallelli L2, Meacci F3, Brugnolli A4, Prosperi L4, Roberta S1, Eccher C1, Mazzoli S3, Lanzafame P5, Caciagli P6, Malossini G1, Bartoletti R7. J Pathog. 2016;2016:1590952. doi: 10.1155/2016/1590952. Epub 2016 Apr 5.
We evaluated, in a preliminary study, the efficacy of umbelliferone, arbutin, and N-acetylcysteine to inhibit biofilm formation on urinary catheter. We used 20 urinary catheters: 5 catheters were incubated with Enterococcus faecalis (control group); 5 catheters were incubated with E. faecalis in presence of umbelliferone (150 mg), arbutin (60 mg), and N-acetylcysteine (150 mg) (group 1); 5 catheters were incubated with E. faecalis in presence of umbelliferone (150 mg), arbutin (60 mg), and N-acetylcysteine (400 mg) (group 2); and 5 catheters were incubated with E. faecalis in presence of umbelliferone (300 mg), arbutin (60 mg), and N-acetylcysteine (150 mg) (group 3). After 72 hours, planktonic microbial growth and microorganisms on catheter surface were assessed. In the control group, we found a planktonic load of ≥10(5) CFU/mL in the inoculation medium and retrieved 3.69 × 10(6) CFU/cm from the sessile cells adherent to the catheter surface.
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CAS 497-76-7 Arbutin

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