Arbaclofen Hydrochloride - CAS 63701-55-3
Catalog number: 63701-55-3
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
GABA Receptor
Arbaclofen, the R-enantiomer of baclofen, is a selective gamma-amino butyric acid type B receptor agonist used for autism spectrum disorder and fragile X syndrome in randomized, double blind, placebo controlled trials.
White to off-white solid
(R)-Baclofen hydrochloride; STX 209 hydrochloride; D-Baclofen hydrochloride; (3R)-4-amino-3-(4-chlorophenyl)butanoic acid;hydrochloride;
Soluble in DMSO
Store at -20 °C
A selective gamma-amino butyric acid type B receptor agonist used for autism spectrum disorder
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Melting Point:
220-222 °C
Canonical SMILES:
Current Developer:
Seaside Therapeutics
1.Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats.
Thomas DA;Navarrete IM;Graham BA;McGowan MK;Hammond DL Brain Res. 1996 Apr 29;718(1-2):129-37.
This study examined the sites in the central nervous system at which subcutaneously-administered R(+)-baclofen hydrochloride (baclofen), the most active isomer of this prototypic gamma-aminobutyric acid (GABA)B receptor agonist, acts to produce antinociception in the rat. To determine whether baclofen acts in the spinal cord, either saline or the GABAB receptor antagonist CGP 35348 was injected intrathecally in rats pretreated 24 min earlier with 1 or 3 mg/kg s.c. baclofen. Intrathecal (i.t.) injection of 3 or 10 micrograms of CGP 35348 antagonized the increase in tail-flick and hot-plate latency produced by either dose of baclofen. To determine whether baclofen acts at sites in the ventromedial medulla (VMM), either saline or CGP 35348 was microinjected in the nucleus raphe magnus or nucleus reticularis gigantocellularis pars alpha of rats pretreated 24 min earlier with 1 or 3 mg/kg s.c. baclofen. Microinjection of 0.5 or 3 micrograms of CGP 35348 at sites in the VMM produced at best only a very modest attenuation of the antinociceptive effects of baclofen. These data suggest that systemically-administered baclofen acts at sites in both the spinal cord and the VMM, but that its antinociceptive effects are likely to be mediated to a greater extent by a spinal, rather than medullary site of action.
2.Transition metal-catalyzed asymmetric reactions using P-chirogenic diaminophosphine oxides: DIAPHOXs.
Nemoto T Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1213-28.
This review describes the development of a new class of chiral phosphorus ligands: amino acid-derived P-chirogenic diaminophosphine oxides, DIAPHOXs, and their application to several transition metal-catalyzed asymmetric allylic substitution reactions. Pd-catalyzed asymmetric allylic alkylation with cyclic beta-keto esters as prochiral nucleophiles was initially examined using P-chirogenic diaminophosphine oxide 1a, resulting in highly enantioselective construction of quaternary stereocenters. Mechanistic investigations revealed that 1a is activated by N,O-bis(trimethylsilyl)acetamide-induced tautomerization to afford a trivalent diamidophosphite species 13, which functions as the actual ligand. Pd-catalyzed asymmetric allylic substitutions of both acyclic and cyclic substrates were also examined using various nucleophiles such as malonate derivatives, nitromethane, aliphatic amines, and aromatic amines, providing a variety of chiral compounds with good to excellent enantioselectivity. In addition, Ir-catalyzed asymmetric allylic amination and alkylation of terminal allylic carbonates were examined using structurally optimized P-chirogenic diaminophosphine oxides, and the corresponding branched products were obtained in a highly regio- and enantioselective manner.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related GABA Receptor Products

CAS 185391-33-7 TCS 1105

TCS 1105
(CAS: 185391-33-7)

TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand that acts as an agonist at α2 and antagonist at α1 benzodiazepine receptors (Ki = 118 and 245 nM, respe...

CAS 1135210-68-2 Tracazolate hydrochloride

Tracazolate hydrochloride
(CAS: 1135210-68-2)

Tracazolate hydrochloride is a subtype-selective GABAA receptor modulator that potentiates or inhibits recombinant GABAA function depending on subunit combinati...

CAS 85118-33-8 THIP hydrochloride

THIP hydrochloride
(CAS: 85118-33-8)

THIP hydrochloride is a GABAA receptor agonist and GABAA-ρ receptor antagonist. THIP exhibits antinociceptive, anticonvulsant and sedative effects. It is used a...

CAS 138729-47-2 Eszopiclone

(CAS: 138729-47-2)

Eszopiclone is an active stereoisomer of zopiclone with hypnotic and sedative activity and without significant anxiolytic activity. Eszopiclone is a GABA A rece...

CAS 194098-25-4 CP-409092

(CAS: 194098-25-4)

CP-409092 is a GABA(A) partial agonist developed for the treatment of General Anxiety Disorder (GAD) and presents an interesting phenomenon of human pharmacokin...

CAS 114012-12-3 Phaclofen

(CAS: 114012-12-3)

Phaclofen, a phosphonic acid derivative of Baclofen, is a selective GABAB antagonist.

CAS 77191-36-7 Nefiracetam

(CAS: 77191-36-7)

Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions.

CAS 840486-93-3 adipiplon

(CAS: 840486-93-3)

Adipiplon is GABAA receptor partial agonist. It can bind to the α3 subtype. Adipiplon is one of the first drugs selected for clinical development which is able ...

CAS 155569-91-8 Emamectin Benzoate

Emamectin Benzoate
(CAS: 155569-91-8)

Emamectin Benzoate is the Emamectin derivative. Emamectin, also called as Proclaim, is widely used as an insecticide because of its chloride channel activation ...

CAS 945828-50-2 AA 29504

AA 29504
(CAS: 945828-50-2)

AA 29504 is a positive allosteric modulator of GABAA receptors with anxiolytic activity. It modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-...

CAS 64603-91-4 Gaboxadol

(CAS: 64603-91-4)

Gaboxadol is a GABA agonist. It was a non-opioid analgesic and a novel type of hypnotic. It was first synthesized in 1977 by the Danish chemist Povl Krogsgaard-...

CAS 128201-89-8 N-ArachidonylGABA

(CAS: 128201-89-8)

N-ArachidonylGABA is first isolated from bovine brain. It was also found to inhibit normal responses to pain in vivo, but has not been fully characterized to da...

CAS 56776-32-0 Etifoxine Hydrochloride

Etifoxine Hydrochloride
(CAS: 56776-32-0)

Etifoxine Hydrochloride is Potentiator of GABAA receptor with anxiolytic and anticonvulsant activity.

CAS 182485-36-5 TPMPA

(CAS: 182485-36-5)

TPMPA is a selective and competitive GABAA-ρ antagonist with 8-fold selectivity for human recombinant ρ1 receptors over ρ2 receptors. TPMPA exhibits minimal eff...

CAS 94-62-2 Piperine

(CAS: 94-62-2)

Piperine (1-Piperoylpiperidine) is an alkaloid isolated from black pepper, activating transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 µ...

CAS 73604-30-5 (-)-Bicuculline methobromide

(-)-Bicuculline methobromide
(CAS: 73604-30-5)

(-)-Bicuculline methobromide is the methobromide salt of (+)-bicuculline, which is a potent antagonist of GABAA receptors.

CAS 1134-47-0 Baclofen

(CAS: 1134-47-0)

Baclofen, an agonist of GABAB receptor, could be effective as a skeletal muscle relaxant and has been also found to have antispastic effect.

CAS 104104-50-9 SR 95531 hydrobromide

SR 95531 hydrobromide
(CAS: 104104-50-9)

SR 95531 hydrobromide is a competitive GABAA receptor antagonist. SR 95531 differs from bicuculline that it selectively antagonizes GABA-induced Cl- currents bu...

CAS 127729-35-5 SKF 97541

SKF 97541
(CAS: 127729-35-5)

SKF 97541 is a highly potent GABAB agonist, and also acts as a GABAA-ρ antagonist. SKF 97541 exhibits sedative effects in mammals and has the potential to be us...

CAS 62666-20-0 Progabide

(CAS: 62666-20-0)

Progabide is a gamma-aminobutyric acid (GABA) antagonist. It has agonistic activity for both the GABAA and GABAB receptors. It has antiepileptic activity and is...

Chemical Structure

CAS 63701-55-3 Arbaclofen Hydrochloride

Quick Inquiry

Verification code

Featured Items