AR03 - CAS 510721-85-4
Category: Inhibitor
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AR03 is a specific inhibitor of apurinic/apyrimidinic (AP) endonuclease 1 (APE1).
Brife Description:
APE1 inhibitor
BMH-23; BMH 23; BMH23; AR03; AR 03; AR-03; 2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine
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1.Monitoring of organic micropollutants in Ghana by combination of pellet watch with sediment analysis: e-waste as a source of PCBs.
Hosoda J;Ofosu-Anim J;Sabi EB;Akita LG;Onwona-Agyeman S;Yamashita R;Takada H Mar Pollut Bull. 2014 Sep 15;86(1-2):575-581. doi: 10.1016/j.marpolbul.2014.06.008. Epub 2014 Jul 3.
Plastic resin pellets collected at 11 beaches covering the whole Ghanaian coastline were analyzed for polychlorinated biphenyls (PCBs). PCB concentrations (∑13 congeners) were higher in Accra, capital city, and Tema (39-69 ng/g-pellets) than those in rural coastal towns (1-15 ng/g-pellets) which are close to global background, indicating local inputs of PCBs. River sediments were also analyzed for PCBs together with molecular markers. Sedimentary PCBs concentrations were highest at a site (AR02) downstream of an electronic waste (e-waste) scrapyard. At the site (AR02), concentration of linear alkylbenzenes (LABs), a marker of municipal wastewater, was lower than another site (AR03) which is located at the downstream of downtown Accra. This result suggests that PCBs are introduced more to the river from the e-waste site than from activities in downtown Accra. PAHs concentrations were relatively higher in urban areas with strong petrogenic signature. Abundance of triphenylbenzenes suggested plastic combustion near e-waste scrapyard.
2.Endoglucanase and xylanase production by Bacillus sp. AR03 in co-culture.
Hero JS;Pisa JH;Perotti NI;Romero CM;Martínez MA Prep Biochem Biotechnol. 2017 Jul 3;47(6):589-596. doi: 10.1080/10826068.2017.1280826. Epub 2017 Jan 20.
The behavior of three isolates retrieved from different cellulolytic consortia, Bacillus sp. AR03, Paenibacillus sp. AR247 and Achromobacter sp. AR476-2, were examined individually and as co-cultures in order to evaluate their ability to produce extracellular cellulases and xylanases. Utilizing a peptone-based medium supplemented with carboxymethyl cellulose (CMC), an increase estimation of 1.30 and 1.50 times was obtained by the co-culture containing the strains AR03 and AR247, with respect to enzyme titles registered by their individual cultivation. On the contrary, the extracellular enzymatic production decreased during the co-cultivation of strain AR03 with the non-cellulolytic Achromobacter sp. AR476-2. The synergistic behavior observed through the combined cultivation of the strains AR03 and AR247 might be a consequence of the consumption by Paenibacillus sp. AR247 of the products of the CMC hydrolysis (i.e., cellobiose and/or cello-oligosaccharides), which were mostly generated by the cellulase producer Bacillus sp. AR03. The effect observed could be driven by the requirement to fulfill the nutritional supply from both strains on the substrate evaluated. These results would contribute to a better description of the degradation of the cellulose fraction of the plant cell walls in nature, expected to an efficient utilization of renewable sources.
3.Synergistic Effect of Simple Sugars and Carboxymethyl Cellulose on the Production of a Cellulolytic Cocktail from Bacillus sp. AR03 and Enzyme Activity Characterization.
Manfredi AP;Pisa JH;Valdeón DH;Perotti NI;Martínez MA Appl Biochem Biotechnol. 2016 Apr;179(1):16-32. doi: 10.1007/s12010-015-1976-5. Epub 2016 Jan 21.
A cellulase-producing bacterium isolated from pulp and paper feedstock, Bacillus sp. AR03, was evaluated by means of a factorial design showing that peptone and carbohydrates were the main variables affecting enzyme production. Simple sugars, individually and combined with carboxymethyl cellulose (CMC), were further examined for their influence on cellulase production by strain AR03. Most of the mono and disaccharides assayed presented a synergistic effect with CMC. As a result, a peptone-based broth supplemented with 10 g/L sucrose and 10 g/L CMC maximized enzyme production after 96 h of cultivation. This medium was used to produce endoglucanases in a 1-L stirred tank reactor in batch mode at 30 °C, which reduced the fermentation period to 48 h and reaching 3.12 ± 0.02 IU/mL of enzyme activity. Bacillus sp. AR03 endoglucanases showed an optimum temperature of 60 °C and a pH of 6.0 with a wide range of pH stability. Furthermore, presence of 10 mM Mn(2+) and 5 mM Co(2+) produced an increase of enzyme activity (246.7 and 183.7 %, respectively), and remarkable tolerance to NaCl, Tween 80, and EDTA was also observed. According to our results, the properties of the cellulolytic cocktail from Bacillus sp.
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CAS 510721-85-4 AR03

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