|Description||AR-C126313, a thiouracil derivative, has been found to be a competitive P2Y2 receptor antagonist and could inhibit P2Y2 receptor-induced β-arrestin translocation in vitro.|
|Purity||≥97% by HPLC|
|Synonyms||AR-C126313; ARC126313; AR C126313; 5-[[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-2H-tetrazol-5-yl-2-furancarboxamide|
Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes.
MRS 2279 is the first broadly applicable, selective and high affinity competitive antagonist radioligand for a P2Y receptor (Ki = 2.5 nM; IC50 = 51.6 nM).
MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.
INS-37217, also known as Denufosol, is a long- acting P2Y2 receptor agonist potentially for the treatment of cystic fibrosis. INS-37217 exhibits an EC50 of ~10 ...
AR-C 66096 tetrasodium salt
The sodium salt form of AR-C 66096, which has been found to be a P2Y12 receptor antagonist and could be probably used as an antithrombotic agent.
Clopidogrel, a thienopyridine derivative, could be used in the prevention and treatment of sorts of arterial circulation disorders caused by platelet aggregatio...
Prasugrel is a thienopyridine prodrug that is converted by esterases to a receptor antagonist for purinergic P2Y12 receptors. The blockade of P2Y12 receptor act...
5-OMe-UDP trisodium salt
5-OMe-UDP trisodium salt is a P2Y6 agonist with EC50 value of 0.08 μM.