|Description||AR 244555 is an inverse agonist of Mas G-protein signaling (IC50 values 186 and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively). AR 244555 inhibited inositol 1,4,5-trisphosphate accumulation in AdMas-infected cells and attenuated the sarcomeric organization and cell enlargement observed in Mas overexpressing myocytes. AR 244555 caused an increase in coronary flow in rat hearts without causing arrhythmias, and provides protection from ischemia-reperfusion injury if administered either before ischemia or immediately before reperfusion.|
|Brife Description||Mas G-protein signaling agonist|
|Synonyms||AR244555; AR 244555; AR-244555; (1'-but-3-enyl-5-chlorospiro[2H-indole-3,4'-piperidine]-1-yl)-(2,6-difluorophenyl)methanone|
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