APS-2-79 - CAS 2002381-25-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H21N3O3
Molecular Weight:
387.43
COA:
Inquire
Targets:
MEK
Description:
APS-2-79 is a small molecule antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site, and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2).
Publictions citing BOC Sciences Products
  • >> More
Appearance:
Solid powder
Synonyms:
6,7-Dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine; APS-2-79; APS 2-79; APS2-79; APS-279; APS 279; APS279.
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
528.6±50.0 °C at 760 Torr
Density:
1.246±0.06 g/cm3
InChIKey:
PEKZLFZZBGBOPJ-UHFFFAOYSA-N
InChI:
1S/C23H21N3O3/c1-15-11-17(29-16-7-5-4-6-8-16)9-10-19(15)26-23-18-12-21(27-2)22(28-3)13-20(18)24-14-25-23/h4-14H,1-3H3,(H,24,25,26)
Canonical SMILES:
CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=C4C=C(OC)C(OC)=CC4=NC=N3
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related MEK Products


CAS 606143-89-9 Binimetinib

Binimetinib
(CAS: 606143-89-9)

Binimetinib is an oral, highly selective MEK inhibitor.

CAS 1236699-92-5 Pimasertib

Pimasertib
(CAS: 1236699-92-5)

Pimasertib, also known as AS703026, SAR245509, MSC1936369B, is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineop...

SMK-17
(CAS: 765958-29-0)

SMK-17 is a MEK1/2 inhibitor. It can inhibit MEK1 kinase activity in a non-ATP-competitive manner and it is highly selective to MEK1 and 2. SMK-17 can inhibit t...

CAS 167869-21-8 PD98059

PD98059
(CAS: 167869-21-8)

PD98059 is a potent and selective inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK kinase). It mediates its inhibitory properties by binding...

CAS 934662-91-6 Cobimetinib racemate

Cobimetinib racemate
(CAS: 934662-91-6)

Cobimetinib racemate is a selective inhibitor of MEK. It is also known as mitogen activated protein kinase kinase (MAPKK) and is a key component of the RAS/RAF/...

CAS 946128-88-7 RO5126766

RO5126766
(CAS: 946128-88-7)

RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-ne...

CAS 334951-92-7 BIX 02188

BIX 02188
(CAS: 334951-92-7)

Selective dual MEK5 kinase inhibitor, with IC50 values of 4.3, 810, 1800, and >6300 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.

CAS 548756-68-9 PD 334581

PD 334581
(CAS: 548756-68-9)

PD 334581, an analog of PD 184352, is an inhibitor of MEK1 that is used in biological studies to evaluate halogen bonding as a novel interaction for rational dr...

CAS 334949-59-6 BIX02188

BIX02188
(CAS: 334949-59-6)

CAS 1265916-41-3 BIX02189

BIX02189
(CAS: 1265916-41-3)

Selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases ...

CAS 1173097-76-1 U0126-EtOH

U0126-EtOH
(CAS: 1173097-76-1)

U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059.

BI-847325
(CAS: 1207293-36-4)

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B...

CAS 923032-37-5 Refametinib

Refametinib
(CAS: 923032-37-5)

Refametinib, also known as RDEA119, BAY 86-9766, is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor RDEA119...

CAS 1035555-63-5 TAK-733

TAK-733
(CAS: 1035555-63-5)

TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. MEK inhibitor TAK-733 selectively b...

CAS 869357-68-6 AZD-8330

AZD-8330
(CAS: 869357-68-6)

AZD8330 is an orally active, selective MEK inhibitor with potential antineoplastic activity. AZD8330 specifically inhibits mitogen-activated protein kinase kina...

Cobimetinib hemifumarate
(CAS: 1369665-02-0)

Cobimetinib, also known as GDC-0973 and XL-518, is a novel selective MEK inhibitor, and the IC50value against MEK1 is 4.2 nM, with potential antineoplastic acti...

CAS 391210-10-9 PD-0325901

PD-0325901
(CAS: 391210-10-9)

PD-0325901 i a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential an...

CAS 1168091-68-6 GDC-0623

GDC-0623
(CAS: 1168091-68-6)

GDC-0623 is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated pro...

CAS 391210-00-7 PD318088

PD318088
(CAS: 391210-00-7)

PD318088 is a MEK inhibitor

CAS 305350-87-2 SL327

SL327
(CAS: 305350-87-2)

SL327 is a MEK inhibitor. SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion. SL327 had no affect on acquisition, expres...

Chemical Structure

CAS 2002381-25-9 APS-2-79

Quick Inquiry

Verification code

Featured Items