APS-2-79 - CAS 2002381-25-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H21N3O3
Molecular Weight:
387.43
COA:
Inquire
Targets:
MEK
Description:
APS-2-79 is a small molecule antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site, and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2).
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Appearance:
Solid powder
Synonyms:
6,7-Dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine; APS-2-79; APS 2-79; APS2-79; APS-279; APS 279; APS279.
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
528.6±50.0 °C at 760 Torr
Density:
1.246±0.06 g/cm3
InChIKey:
PEKZLFZZBGBOPJ-UHFFFAOYSA-N
InChI:
1S/C23H21N3O3/c1-15-11-17(29-16-7-5-4-6-8-16)9-10-19(15)26-23-18-12-21(27-2)22(28-3)13-20(18)24-14-25-23/h4-14H,1-3H3,(H,24,25,26)
Canonical SMILES:
CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=C4C=C(OC)C(OC)=CC4=NC=N3
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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CAS 2002381-25-9 APS-2-79

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