|Description||Aprepitant is a specific NK-1R antagonist, used as an antiemetic agent.|
|Appearance||white solid powder|
|Synonyms||Emend, L-754030; MK-0869; ONO-7436.|
A selective agonist of tachykinin NK1 receptor
RP 67580 is a selective non-peptide tachykinin NK1 receptor antagonist with Ki of 2.9 nM, and shows no activity ofr NK2 and NK3 (Ki>10 uM). It exhibits antinoci...
MEN11467, a pseudopeptide,is a new tachykinin NK1 receptor antagonist which potently antagonizes both tachykinin and antigen-mediated inflammatory responses of ...
Physalaemin, a non-mammalian tachykinin originally isolated from the Physalaemus frog, binds selectively to neurokinin-1 (NK1) receptor with high affinity.
SSR 146977 hydrochloride
SSR 146977 hydrochloride is a potent and selective NK3 receptor antagonist (Ki = 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor, respec...
MEN 10376 is a selective NK2 receptor antagonist.
CP 99994 dihydrochloride
The hydrochloride salt form of CP 99994, which is a high affinity NK1 antagonist and could attenuate endothelium-dependent contraction induced by substance P.
GR 64349 is a potent and selective agonist of tachykinin NK2 receptor (EC50 = 3.7 nM in rat colon).
SR 140333 is a potent NK1 receptor antagonist (Ki = 0.74 nM. IC50 = 1.6 nM). SR 140333 inhibits substance P-invoked calcium mobilization and outward current (IC...
Talnetant is the hydrochloride salt of Talnetant. Talnetant, also called as SB 223412, is a selective, competitive, nonpeptide NK3 receptor antagonist and is in...
Kassinin, a tachykinin peptide derived from the Kassina frog, is secreted as a defense response, and is involved in neuropeptide signalling and shows selectivit...
Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the activity o...
Neurokinin B, one of the tachykinin family of peptides, binds a family of GPCRs—including neurokinin receptor 1 (NK1R), NK2R, and NK3R to mediate their biologic...
An agonist of neurokinin 2 (NK2) receptor
Substance P, a neuropeptide, is a sensory neuropeptide and inflammatory mediator. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor...
Fosaprepitant (L-758298) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.
L-732,138 is a highly selective and potent substance P (SP) receptor antagonist. It is also a potent and competitive tachykinin NK1 receptor antagonist with IC5...
Osanetant is a non-peptide neurokinin 3 (NK3) receptor antagonist. It is developed for the treatment of schizophrenia and other central nervous system (CNS) dis...
Neurokinin A (4-10), an endogenous neuromodulatory peptide formerly known as substance K, is atachykinin NK2 receptor agonist.
GR 159897 is a potent and selective neurokinin NK2 receptor antagonist. GR 159897 competes for binding of [3H]GR100679 to hNK2-transfected CHO cells (pKi = 9.5)...