Apigenin - CAS 520-36-5
Catalog number:
B0084-070356
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H10O5
Molecular Weight:
270.24
COA:
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Targets:
Others
Description:
Apigenin (4’,5,7-trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides. Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 μM.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-070356 500 mg $190 In stock
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Brife Description:
P450 inhibitor for CYP2C9
Purity:
>98%
Synonyms:
NSC 83244; LY 080400; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; Chamomile; Spigenin; Versulin
MSDS:
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InChIKey:
KZNIFHPLKGYRTM-UHFFFAOYSA-N
InChI:
InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
Canonical SMILES:
C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
1.Efficacy of cocoa pod extract as antiwrinkle gel on human skin surface.
Abdul Karim A1, Azlan A2,3,4, Ismail A2, Hashim P3, Abd Gani SS3, Zainudin BH1, Abdullah NA1. J Cosmet Dermatol. 2016 Apr 4. doi: 10.1111/jocd.12218. [Epub ahead of print]
OBJECTIVE: Cocoa pods are abundant waste materials of cocoa plantation, which are usually discarded onto plantation floors. However, due to poor plantation management, the discarded cocoa pods can create suitable breeding ground for Phytophthora palmivora, which is regarded as the causal agent of the black pod disease. On the other hand, cocoa pods potentially contain antioxidant compounds. Antioxidant compounds are related to the protection of skin from wrinkles and can be used as functional cosmetic ingredients. Therefore, in this study, cocoa pods were extracted and to be used as active ingredients for antiwrinkles.
2.Phenolic composition and antiparasitic activity of plants from the Brazilian Northeast "Cerrado".
Calixto Júnior JT1, de Morais SM1, Gomez CV2, Molas CC2, Rolon M2, Boligon AA3, Athayde ML3, de Morais Oliveira CD4, Tintino SR4, Henrique Douglas MC4. Saudi J Biol Sci. 2016 May;23(3):434-40. doi: 10.1016/j.sjbs.2015.10.009. Epub 2015 Oct 23.
This work describes the antiparasitic and cytotoxic activities of three plant species from the Cerrado biome, Northeastern Brazil. Significant antiparasitic inhibition was observed against Trypanosoma cruzi (63.86%), Leishmania brasiliensis (92.20%) and Leishmania infantum (95.23%) when using ethanol extract from leaves of Guazuma ulmifolia Lam. (Malvaceae), at a concentration of 500 μg/mL. However, low levels of inhibition were observed when assessing leishmanicidal and trypanocidal (Clone CL-B5) activities of crude ethanol extracts from leaves and bast tissue of Luehea paniculata (Malvaceae) and leaves and bark of Prockia crucis (Salicaceae) at a concentration of 500 μg/mL. The extracts revealed the presence of phenolic acids such as gallic acid, chlorogenic acid, caffeic acid and rosmarinic acid, as well as flavonoids such as rutin, luteolin, apigenin and quercetin - the latter detected only in G. ulmifolia. G. ulmifolia extract displayed higher leishmanicidal activity probably due to the presence of quercetin, a potent known leishmanicidal compound.
3.Gracilone, a new sesquiterpene lactone from Tanacetum gracile (Tansies).
Bhat G1,2, Masood A2, Ganai BA3, Hamza B4, Ganie S4, Shafi T5, Idris A6, Shawl AS1, Tantry MA3. Nat Prod Res. 2016 Mar 27:1-8. [Epub ahead of print]
The methanolic extract of the Tanacetum gracile afforded the isolation of new sesquiterpene lactone, named gracilone (1) along with four known compounds as 14α-taraxeran-3-one (2), 14α-taraxeran-3-ol (3), apigenin (4) and β-sitosterol (5). The structure of compound 1 was elucidated on the basis of 1D, 2D NMR and MS spectroscopic analysis. Antimicrobial, antioxidant and anticancer activities of all compounds were evaluated, from which gracilone (1) showed a moderate antibacterial activity, while apigenin (4) showed comparatively more antibacterial activity against both gram-positive and gram-negative tested strains.
4.[Chemical constituents from whole plants of Valeriana hardwickii].
Chai SW, Zhai YS, Wang MY. Zhongguo Zhong Yao Za Zhi. 2015 Oct;40(20):4007-11.
Chemical investigation of the whole plants of Valeriana hardwickii has led to the isolation of 11 flavones and 2 monoterpe- noids by using various chromatographic techniques including column chromatography on silica gel and Sephadex LH-20, preparative TLC, and preparative HPLC. Their structures were identified by spectroscopic data analysis as syzalterin (1), 6-methylapigenin (2), 5-hydroxy-7,4'-dimethoxyflavone (3), genkwanin (4), acacetin (5), apigenin (6), quercetin (7), tricin (8), (-)-farrerol (9), sosakuranetin (10), 5,3',4'-trihydroxy-7-methoxyflavanone (11), (-)-bornyl ferulate ( 12) , and (-)-bornyl caffeate ( 13). All compounds were isolated from this plant for the first time, while compounds 1, 9-13 were obtained from this genus for the first time.
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CAS 520-36-5 Apigenin

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