APD334 - CAS 1206123-37-6
Catalog number:
1206123-37-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H26F3NO3
Molecular Weight:
457.49
COA:
Inquire
Targets:
Sphingosine 1 Phosphate Receptor
Description:
This active moleclar is a Sphingosine 1 Phosphate Receptor antagonists for treatment of multiple sclerosis (MS) and other autoimmune diseases originated by Arena Pharmaceuticals. APD334 was efficacious in a mouse EAE (experimental autoimmune encephalomyelitis ) model of MS and a rat CIA (collagen induced arthritis) model. It was found to have appreciable central exposure. In Sep 2015, Arena Pharmaceuticals planed a phase II extension trial for Ulcerative colitis in USA was on-going. In Mar 2016, Arena Pharmaceuticals had patent protection for APD 334 in USA, Japan, China, Australia and Russia.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
Etrasimod; UNII-6WH8495MMH; 6WH8495MMH; CHEMBL3358920;2-[(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
multiple sclerosis (MS) and other autoimmune diseases.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
MVGWUTBTXDYMND-QGZVFWFLSA-N
InChI:
InChI=1S/C26H26F3NO3/c27-26(28,29)22-11-15(5-8-19(22)16-3-1-2-4-16)14-33-18-7-10-23-21(13-18)20-9-6-17(12-24(31)32)25(20)30-23/h5,7-8,10-11,13,16-17,30H,1-4,6,9,12,14H2,(H,31,32)/t17-/m1/s1
Canonical SMILES:
C1CCC(C1)C2=C(C=C(C=C2)COC3=CC4=C(C=C3)NC5=C4CCC5CC(=O)O)C(F)(F)F
Current Developer:
Originator: Arena Pharmaceuticals
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Sphingosine 1 Phosphate Receptor Products


CAS 1202073-26-4 AMG 369

AMG 369
(CAS: 1202073-26-4)

This active molecular is a S1P1/S1P5 agonist with limited activity at S1P3. AMG 369 has no activity at S1P2 and S1P4. AMG-369 is shown to reduce blood lymphocyt...

APD334
(CAS: 1206123-37-6)

This active moleclar is a Sphingosine 1 Phosphate Receptor antagonists for treatment of multiple sclerosis (MS) and other autoimmune diseases originated by Aren...

BMS-520
(CAS: 1236188-38-7)

This active molecular is a selective S1P1 receptor agonist that originated by Bristol-Myers Squibb. BMS-520 shows really good efficacy in animal models of arthr...

PF-543 hydrochloride
(CAS: 1706522-79-3)

The hydrochloride salt form of PF-543, a novel SphK1 inhibitor that could exhibit activity in induceing necrosis in human colorectal cancer cells in biological ...

CAS 840523-39-9 CS-0777-P

CS-0777-P
(CAS: 840523-39-9)

CS-0777 is a selective sphingosine 1-phosphate receptor modulator agonist. It is in clinical trials for the treatment of multiple sclerosis, but no recent devel...

Siponimod
(CAS: 1230487-85-0)

This active molecular is a selective Sphingosine 1 phosphate (S1P) receptor agonist originated by Novartis. The EC50 value is 0.39nM for S1P1 receptors and 0.98...

Quick Inquiry

Verification code

Featured Items