|Description||AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity.|
|Appearance||Semisolid (wax like)|
|Synonyms||AP 1903; AP-1903|
|Current Developer||ARIAD Pharm. / Bellicum Pharmaceuticals, Inc|
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