AP18 - CAS 55224-94-7
Catalog number:
55224-94-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H12ClNO
Molecular Weight:
209.67
COA:
Inquire
Targets:
TRP Channel
Description:
AP18 is a selective Transient receptor potential A1(TRPA1) channel blocker which reversibly inhibits TRPA1 with IC50 values of 3.1 and 4.5 µM at human and mouse respectively. It has been used to study TRPA1 signaling in mice and rats as well as in vitro. It blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. It also blocks cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. It reverses CFA-induced mechanical hyperalgesia in mice.
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Purity:
98%
Appearance:
White to off-white solid
Synonyms:
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime;AP-18;4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime;(NE)-N-[(Z)-4-(4-chlorophenyl)-3-methylbut-3-en-2-ylidene]hydroxylamine;(2E,3E)-4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime
Solubility:
DMSO: >10 mg/mL
Storage:
2-8ºC
MSDS:
Inquire
Application:
AP18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis.
Quality Standard:
In-house standard
Quantity:
Milligrams-Grams
Boiling Point:
348.4±34.0 °C | Condition: Press: 760 Torr
Density:
1.09±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
MHTJEUOFLVQMCL-XTYDYKDCSA-N
InChI:
InChI=1S/C11H12ClNO/c1-8(9(2)13-14)7-10-3-5-11(12)6-4-10/h3-7,14H,1-2H3/b8-7-,13-9+
Canonical SMILES:
CC(=CC1=CC=C(C=C1)Cl)C(=NO)C
1.Smooth muscle-depressant activity of AP-18, a putative TRPA1 antagonist in the guinea pig intestine.
Bartho L1, Sándor Z, Kelemen D, Papp R, Benko R. Pharmacology. 2014;94(3-4):131-4. doi: 10.1159/000366023. Epub 2014 Sep 18.
AP-18, a putative antagonist at TRPA1 receptor/ion channel, caused smooth muscle relaxation at 10-100 µmol/l. It inhibited cholinergic twitch responses evoked by electrical field stimulation of cholinergic nerves as well as contractions in response to acetylcholine and histamine in the guinea pig small intestine. AP-18 (30 µmol/l) blocked spontaneous contractions of longitudinal strips of human jejunum. It is concluded that AP-18 may have limited value in studying TRPA1-mediated responses in smooth muscles and should probably be used with care in other preparations because of possible nonspecific effects.
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CAS 55224-94-7 AP18

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