Antazoline hydrochloride - CAS 2508-72-7
Catalog number: 2508-72-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C17H19N3.HCl
Molecular Weight:
301.81
COA:
Inquire
Targets:
Histamine Receptor
Description:
Antazoline HCl is a first generation antihistamine, binding to the histamine H1 receptor and blocking the action of endogenous histamine.
Purity:
>98%
Synonyms:
Phenazocine HCl
MSDS:
Inquire
InChIKey:
SWKDMSRRIBZZAY-UHFFFAOYSA-N
InChI:
InChI=1S/C17H19N3.ClH/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;/h1-10H,11-14H2,(H,18,19);1H
Canonical SMILES:
C1CN=C(N1)CN(CC2=CC=CC=C2)C3=CC=CC=C3.Cl
1.A review of the use of olopatadine in allergic conjunctivitis
James I. McGill. International Ophthalmology 25: 171–179, 2004.
The relative functional potency of olopatadine at ocular H1-receptors has been measured by looking at intracellular phospoinositide (PI) turnover or calcium mobilization (both involved in mast cell degranulation) and by measuring extracellular release of appropriate cytokines. In studies of this type, olopatadine has been shown to antagonize histamine-induced PI turnover in cultured human conjunctival epithelial cells (IC50 = 9.5–10 nM), human corneal fibroblasts (IC50 = 15.8–19 nM) and transformed human trabecular meshwork cells (IC50 = 31.6–39.9 nM). In a further comparative study, primary human conjunctival epithelial cell cultures were stimulated with histamine in the presence or absence of a variety of anti-histamines. Antazoline hydrochloride, emedastine difumarate, levocabastine hydrochloride, olopatadine hydrochloride and pheniramine maleate were all shown to attenuate histamine-stimulated phosphatidylinositol turnover and IL-6 and IL-8 secretion. Emedastine was the most potent, with IC50 1–3 nM, while olopatadine was of similar potency to levocabastine and far more potent than antazoline and pheniramine. Olopatadine was of similar potency to emedastine as an inhibitor of cytokine secretion (IC50 1.7–5.5 nM) and more potent than the other three antihistamines tested.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Histamine Receptor Products


CAS 135-87-5 Piperoxane hydrochloride

Piperoxane hydrochloride
(CAS: 135-87-5)

Piperoxan is an antihistamine drug which is derived from benzodioxan. At first it was investigated by Fourneau as an α-adrenergic-blocking agent, then they foun...

CAS 80012-43-7 Epinastine

Epinastine
(CAS: 80012-43-7)

Epinastine is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is highly selective for ...

CAS 34839-70-8 Metiamide

Metiamide
(CAS: 34839-70-8)

Metiamide is developed from another burimamide, used as a histamine H2 receptor antagonist.

CAS 77-38-3 Chlorphenoxamine

Chlorphenoxamine
(CAS: 77-38-3)

Chlorphenoxamine is an analog of diphenhydramine. It has antimuscarinic and antihistaminic properties. It has been used as an antipruritic and antiparkinsonian ...

CAS 929622-09-3 Bavisant dihydrochloride

Bavisant dihydrochloride
(CAS: 929622-09-3)

Bavisant dihydrochloride is the dihydrochloride form of Bavisant, which is a highly selective, orally active antagonist of the human H3 receptor. It may be used...

CAS 129-74-8 Buclizine hydrochloride

Buclizine hydrochloride
(CAS: 129-74-8)

Buclizine hydrochloride is an antihistamine and anticholinergic of the piperazine derivative family.

CAS 1222097-72-4 S38093 HCl

S38093 HCl
(CAS: 1222097-72-4)

S38093 HCl is a histamine H3 antagonist/inverse agonist.

CAS 482-15-5 Isothipendyl

Isothipendyl
(CAS: 482-15-5)

Isothipendyl is a first-generation histamine H1 antagonist with anticholinergic activity. It has been used as an antipruritic.

Chemical Structure

CAS 2508-72-7 Antazoline hydrochloride

Quick Inquiry

Verification code

Featured Items