Anisotropine methyl bromide - CAS 80-50-2
Catalog number:
80-50-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C₁₇H₃₂BrNO₂
Molecular Weight:
362.35
COA:
Inquire
Targets:
mAChR
Description:
Anisotropine methylbromide is a muscarinic antagonist and antispasmodic. It was an adjunct in the treatment of peptic ulcer and promoted as being more specific to the gastrointestinal tract than other anticholinergics. But now, anisotropine methylbromide has been superseded by more effective agents in the treatment of peptic ulcer disease.
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Purity:
98%
Appearance:
Powder
Synonyms:
(3-endo)-8,8-Dimethyl-3-[(1-oxo-2-propylpentyl)oxy]-8-azoniabicyclo[3.2.1]octane Bromide; 3α-Hydroxy-8-methyl-1αH,5αH-tropanium Bromide 2-Propylvalerate; endo-8,8-Dimethyl-3-[(1-oxo-2-propylpentyl)oxy]- 8-azoniabicyclo[3.2.1]octane Bromide; 8-Methyltropinium Bromide, 2-Propylvalerate; 8-Methyl-3-(2-propylpentanoyloxy)tropinium Bromide; 8-Methyltropinium Bromide 2-Propylpentanoate; Anisotropine Methobromide; Lytispasm; Octatropine Methylbromide; Valpin; Valpin 50; Vapin
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
peptic ulcer
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
QSFKGMJOKUZAJM-JXMYBXCISA-M
InChI:
InChI=1S/C17H32NO2.BrH/c1-5-7-13(8-6-2)17(19)20-16-11-14-9-10-15(12-16)18(14,3)4;/h13-16H,5-12H2,1-4H3;1H/q+1;/p-1/t14-,15+,16?;
Canonical SMILES:
CCCC(CCC)C(=O)OC1CC2CCC(C1)[N+]2(C)C.[Br-]
1.Effect of nighttime anisotropine methyl bromide of duodenal ulcer healing and pain: a double-blind controlled trial.
Bowers JH, Forbes JA, Freston JW. J Clin Pharmacol. 1978 Jul;18(7):365-71.
Anisotropine methyl bromide, an anticholinergic, 80 mg given orally at 8 P.M., suppresses gastric acid secretion through the night without significant side effects. Thirty patients with endoscopy-proved symptomatic duodenal ulcer disease completed a randomized, double-blind, placebo-controlled trial of nighttime anisotropine methyl bromide therapy. Eleven (69 per cent) of 16 anisotropine methyl bromide-treated and six (43 per cent) of 14 placebo-treated subjects healed their ulcers within two weeks of starting treatment. The anisotropine methyl bromide-treated subjects averaged 0.63 +/- 0.27 (mean +/- S.E.) episodes of nocturnal pain during the treatment period versus 2.71 +/- 1.08 episodes in the placebo group (P = 0.06). This is the first reported study of this type designed to evaluate the efficacy of an anticholinergic agent in the healing of duodenal ulcers. Although not conclusive, the results suggest nighttime anisotropine methyl bromide therapy may be useful in the treatment of duodenal ulcer disease.
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CAS 80-50-2 Anisotropine methyl bromide

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