Anisindione - CAS 117-37-3
Catalog number: 117-37-3
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C16H12O3
Molecular Weight:
252.26
COA:
Inquire
Targets:
Others
Description:
Anisindione, an anticoagulant, could avoid the generation of active procoagulation factors and sorts of proteins in the liver.
Purity:
98%
Appearance:
Powder
Synonyms:
Anisindione; Miradon; Anisin indandione; Unidone; 2-(4-Methoxyphenyl)-1H-indene-1,3(2H)-dione
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Anisindione is an anticoagulant and could avoid the generation of active procoagulation factors and sorts of proteins in the liver.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
InChIKey:
XRCFXMGQEVUZFC-UHFFFAOYSA-N
InChI:
InChI=1S/C16H12O3/c1-19-11-8-6-10(7-9-11)14-15(17)12-4-2-3-5-13(12)16(14)18/h2-9,14H,1H3
Canonical SMILES:
COC1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O
1.3-(2-Methoxyphenyl)-1H-2-benzopyran-1-one.
Prince P;Miller JA;Fronczek FR;Gandour RD Acta Crystallogr C. 1989 Jul 15;45 ( Pt 7):1086-7.
C16H12O3, Mr = 252.3, orthorhombic, Pna21, a = 6.633 (3), b = 13.367 (2), c = 14.056 (2) A, V = 1246.3 (9) A3, Z = 4, Dx = 1.344 g cm-3, lambda (Cu K alpha) = 1.54184 A, mu = 7.17 cm-1, F(000) = 528, T = 296 K, R = 0.027 for 2337 observations (of 2508 unique date). The average deviation from planarity is 0.013 (1) A with a maximum of 0.028 (1) A for the fused-rings system, and 0.003 (1) A with a maximum of 0.005 (1) A for the methoxyphenyl ring. The dihedral angle between the two systems is 4.7 (3) degrees. The methoxyphenyl ring is pushed away from the vinyl proton and towards the endocyclic O atom; the bond angles are 130.13 (9) and 110.13 (8) degrees, respectively.
2.Coumarin derivatives and breast-feeding.
Clark SL;Porter TF;West FG Obstet Gynecol. 2000 Jun;95(6 Pt 1):938-40.
Coumarin derivatives are the anticoagulants most widely used in the United States. These agents are relatively contraindicated during pregnancy, and the use of these drugs in breast-feeding women remains controversial. Much of the confusion regarding the passage of these agents into breast milk might stem from the fact that different agents possess significantly different chemical properties. A review of the chemical structure of different coumarin derivatives, as well as available clinical evidence, suggests that warfarin sodium is not excreted into breast milk, and can be safely given to women requiring therapeutic anticoagulation postpartum. For the rare patient who cannot tolerate warfarin sodium, the use of dicumarol, rather than anisindione, is preferred.
3.Anticoagulation with anisindione in patients who are intolerant of warfarin.
Grosset AB;Allen JE;Rodgers GM Am J Hematol. 1994 Jun;46(2):138-40.
Patients who require oral anticoagulation usually receive warfarin. We used an indanedione drug, anisindione, in two patients who were intolerant of warfarin but who needed long-term oral anticoagulation. The use of this alternative oral anticoagulant is reviewed.
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CAS 117-37-3 Anisindione

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