Aniracetam - CAS 72432-10-1
Catalog number: 72432-10-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Aniracetam is a nootropics and neuroprotective drug.
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1.[Real-world analysis of concurrent diseases and medicine use among patients with insomnia].
Cui JF, Yang W, Xie YM, Sun Y, Zhuang Y, Wang YY. Zhongguo Zhong Yao Za Zhi. 2014 Sep;39(18):3519-26.
This study aims to explore and analyze the condition of concurrent diseases and medicine use of traditional Chinese medicine (TCM) and western medicine among the patients with insomnia. One thousand and sxity seven cases of data from 20 national hospitals' hospital information system (HIS) databases were collected. The frequent concurrent diseases included hypertension (26.9%), brain blood supply insufficiency (24.93%), cerebral infarction (19.49%), blood lipoprotein disturbance (15.28%), coronary heart disease (14.15%), headache (10.68%), chronic gastritis (8.81%), type 2 diabetes mellitus (7.87%), depressive disorder (7.4%) and anxiety disorder (6.65%). The 10 most frequently-used western drugs included alprazolam (35.99%), aspirin (25.4%), olanzapine (24.18%), cinepazide (23.06%), flupentixol & melitracen (18.74%), zolpidem (18.37%), oxiracetam (15.65%), estazolam (15%), aniracetam (13.4%) and piracetam (13.31%). The 10 most frequently-used TCM included Shuxuening injection (16.
2.Aniracetam does not alter cognitive and affective behavior in adult C57BL/6J mice.
Elston TW1, Pandian A1, Smith GD2, Holley AJ1, Gao N1, Lugo JN3. PLoS One. 2014 Aug 6;9(8):e104443. doi: 10.1371/journal.pone.0104443. eCollection 2014.
There is a growing community of individuals who self-administer the nootropic aniracetam for its purported cognitive enhancing effects. Aniracetam is believed to be therapeutically useful for enhancing cognition, alleviating anxiety, and treating various neurodegenerative conditions. Physiologically, aniracetam enhances both glutamatergic neurotransmission and long-term potentiation. Previous studies of aniracetam have demonstrated the cognition-restoring effects of acute administration in different models of disease. No previous studies have explored the effects of aniracetam in healthy subjects. We investigated whether daily 50 mg/kg oral administration improves cognitive performance in naïve C57BL/6J mice in a variety of aspects of cognitive behavior. We measured spatial learning in the Morris water maze test; associative learning in the fear conditioning test; motor learning in the accelerating rotarod test; and odor discrimination. We also measured locomotion in the open field test, anxiety through the elevated plus maze test and by measuring time in the center of the open field test.
3.Palladium-Catalyzed Hydroamidocarbonylation of Olefins to Imides.
Li H1, Dong K1, Neumann H1, Beller M2. Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10239-43. doi: 10.1002/anie.201503954. Epub 2015 Jul 23.
Carbonylation reactions allow the efficient synthesis of all kinds of carbonyl-containing compounds. Here, we report a straightforward synthesis of various imides from olefins and CO for the first time. The established hydroamidocarbonylation reaction affords imides in good yields (up to 90 %) and with good regioselectivity (up to 99:1) when applying different alkenes and amides. The synthetic potential of the method is highlighted by the synthesis of Aniracetam by intramolecular hydroamidocarbonylation.
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CAS 72432-10-1 Aniracetam

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