Ani 9 - CAS 356102-14-2
Category: Inhibitor
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Molecular Formula:
C17H17ClN2O3
Molecular Weight:
332.78
COA:
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Targets:
Others
Description:
Ani 9 is a highly selective and potent anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) inhibitor with IC50 value of 77 nM. It completely inhibits ANO1 chloride current with submicromolar potency and displays no effect on ANO2 activity at 10 μM. It does not affect the intracellular calcium signaling, or CFTR chloride channel activity and ENaC channel activity at 30 μM. It may be a useful pharmacological tool for studying ANO1. It may be potential for drug therapy of hypertension, cancer, diarrhea, asthma and pain.
Purity:
≥98% by HPLC
Synonyms:
(4-Chloro-2-methylphenoxy)-acetic acid [(2-methoxyphenyl)methylene]hydrazide; 2-(4-Chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide; 2-(4-Chloro-2-methylphenoxy)-acetic acid 2-[(2-methoxyphenyl)methylene]hydrazide; 2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide
MSDS:
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InChIKey:
KDALDZRKOBJXIE-VXLYETTFSA-N
InChI:
InChI=1S/C17H17ClN2O3/c1-12-9-14(18)7-8-15(12)23-11-17(21)20-19-10-13-5-3-4-6-16(13)22-2/h3-10H,11H2,1-2H3,(H,20,21)/b19-10+
Canonical SMILES:
CC1=C(C=CC(=C1)Cl)OCC(=O)NN=CC2=CC=CC=C2OC
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CAS 356102-14-2 Ani 9

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