Angiotensin I/II (1-7) - CAS 51833-78-4
Catalog number: 51833-78-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Angiotensin Receptor
Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor, inducing vasorelaxation through release of NO and prostaglandins.
White lyophilised solid
Angiotensin II (1-7) heptapeptide; H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH;
Soluble in DMSO
Store at -20 °C
Endogenous peptide fragment.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
1.47 g/cm3
Canonical SMILES:
Current Developer:
Tarix Orphan; Tarix Pharmaceuticals;
1.Perindoprilat changes ANG (1-9) production in renal arteries isolated from young spontaneously hypertensive rats after ANG I incubation.
Wołkow PP1, Bujak-Giżycka B, Jawień J, Olszanecki R, Madej J, Rutowski J, Korbut R. Physiol Res. 2016 Mar 15. [Epub ahead of print]
We used mass spectrometry to quantitate production of angiotensinogen metabolites in renal artery of 3 and 7 months old Wistar-Kyoto (WKY) and Spontaneously Hypertensive Rats (SHR). Tissue fragments were incubated for 15 minutes in oxygenated buffer, with added Angiotensin I. Concentrations of Angiotensins I (ANG I), II (ANG II), III (ANG III), IV (ANG IV), Angiotensin (1-9) [ANG (1-9)], Angiotensin (1-7) [ANG (1-7)], and Angiotensin (1-5) [ANG (1-5)], excreted into the buffer during experiment, were measured using liquid chromatography - mass spectrometry (LC/MS) and expressed per mg of dry tissue. Effects of pretreatment with 10 microM perindoprilat on the production of ANG I metabolites were quantitated. Background production of any of ANG I metabolites differed neither between WKY and SHR rats nor between 3 and 7 months old rats. Perindoprilat pretreatment of renal arteries resulted, as expected, in decrease of ANG II production. However, renal arteries of 7-month-old SHR rats were resistant to ACE inhibitor and did not change ANG II production in response to perindoprilat.
2.Angiotensin-(1-7) counteracts angiotensin II-induced dysfunction in cerebral endothelial cells via modulating Nox2/ROS and PI3K/NO pathways.
Xiao X1, Zhang C1, Ma X2, Miao H3, Wang J1, Liu L1, Chen S1, Zeng R3, Chen Y4, Bihl JC5. Exp Cell Res. 2015 Aug 1;336(1):58-65. doi: 10.1016/j.yexcr.2015.06.010. Epub 2015 Jun 19.
Angiotensin (Ang) II, the main effector of the renin-angiotensin system, has been implicated in the pathogenesis of vascular diseases. Ang-(1-7) binds to the G protein-coupled Mas receptor (MasR) and can exert vasoprotective effects. We investigated the effects and underlying mechanisms of Ang-(1-7) on Ang II-induced dysfunction and oxidative stress in human brain microvascular endothelial cells (HbmECs). The pro-apoptotic activity, reactive oxygen species (ROS) and nitric oxide (NO) productions in HbmECs were measured. The protein expressions of nicotinamide adenine dinucleotide phosphate oxidase 2 (Nox2), serine/threonine kinase (Akt), endothelial nitric oxide synthase (eNOS) and their phosphorylated forms (p-Akt and p-eNOS) were examined by western blot. MasR antagonist and phosphatidylinositol-3-kinase (PI3K) inhibitor were used for receptor/pathway verification. We found that Ang-(1-7) suppressed Ang II-induced pro-apoptotic activity, ROS over-production and NO reduction in HbmECs, which were abolished by MasR antagonist.
3.Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling.
Jin HY1,2, Chen LJ3,4, Zhang ZZ5,6, Xu YL7, Song B8, Xu R9, Oudit GY10, Gao PJ11,12, Zhu DL13,14,15, Zhong JC16,17,18. J Transl Med. 2015 Aug 6;13:255. doi: 10.1186/s12967-015-0616-8.
BACKGROUND: The renin-angiotensin system (RAS) has been implicated in atherosclerotic lesions and progression to chronic kidney diseases. We examined regulatory roles of angiotensin-converting enzyme 2 (ACE2) in the apolipoprotein E (ApoE) knockout (KO) kidneys.
4.Characterization of the renal renin-angiotensin system in transgenic mice that express rat tonin.
Ribeiro AA1, Palomino Z1, Lima MP2, Souza LE3, Ferreira DS4, Pesquero JB4, Irigoyen MC3, Pesquero JL5, Casarini DE6. J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):947-55. doi: 10.1177/1470320315595572. Epub 2015 Jul 27.
INTRODUCTION: Tonin is an enzyme that is able to generate angiotensin II (Ang II) from angiotensin I (Ang I) or directly from angiotensinogen. Our goal was to characterize the renal renin-angiotensin system in transgenic mice that express rat tonin (TGM`(rTon)).
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