(±)-Anatoxin A fumarate - CAS 1219922-30-1
Category: Inhibitor
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Molecular Formula:
C14H19NO5
Molecular Weight:
281.31
COA:
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Targets:
nAChR
Description:
(±)-Anatoxin A fumarate is a secondary, bicyclic amine alkaloid isolated from the blue-green alga A. aquae. It has cyanotoxin with acute neurotoxicity and could cause loss of coordination, muscular fasciculations, convulsions and death by respiratory paralysis. It displays high affinity for nicotinic acetylcholine receptors with Kd value of 0.1-0.2 μM. It binds to α4β2- and α7-type nicotinic receptors with Ki values of 1.3 nM and 1.8 μM, respectively. It stimulates [3H]-dopamine release from striatal synaptosomes with an EC50 value of 134 nM.
Purity:
≥96% by HPLC
Synonyms:
(±)-2-Acetyl-9-aza bicyclo[4.2.1]non-2-ene fumarate; rac-Anatoxin A Fumarate; 1-(9-Azabicyclo[4.2.1]non-2-en-2-yl)ethanone 2-Butenedioate
MSDS:
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InChIKey:
ZJSIFVODFDHYJU-WLHGVMLRSA-N
InChI:
InChI=1S/C10H15NO.C4H4O4/c1-7(12)9-4-2-3-8-5-6-10(9)11-8;5-3(6)1-2-4(7)8/h4,8,10-11H,2-3,5-6H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
Canonical SMILES:
CC(=O)C1=CCCC2CCC1N2.C(=CC(=O)O)C(=O)O
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CAS 1219922-30-1 (±)-Anatoxin A fumarate

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