|Synonyms||ZD-1033; Arimidex; Anastrazole; Anastrozol; ZD1033|
|Description||Anastrozole is an aromatase inhibitor that acts via binding competitively to the hem group of the CYP unit of the enzyme thereby reducing estrogen biosynthesis in the periphery and the breast. Anastrozole has little or no effect on other steroid hormones. It is commonly used as therapy of estrogen receptor positive breast cancer.|
Conquinine is a Cytochrome P450 2D6 inhibitor. It is a dextrorotatory stereoisomer of quinine extracted from the bark of the Cinchona tree and similar plant spe...
Thioridazine is an inhibitor of CYP1A2 and CYP3A2. It is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously wi...
Galeterone (TOK-001 or VN/124-1) is a novel antiandrogen under development by Tokai Pharmaceuticals for the treatment of prostate cancer. It possesses a unique ...
Orterone (TAK-700) is an orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase (17,20 lyase) with potential antiandrog...
VT-464 R enantiomer
The R-enantiomer form of VT-464, a non-steroidal compound, has been found to lead to the reduction of androgen through acting as a human CYP17 lyase inhibitor.
The racemate form of VT-464, a non-steroidal compound, has been found to lead to the reduction of androgen through acting as a human CYP17 lyase inhibitor. IC50...
Abiraterone blocks the synthesis of androgens by inhibiting CYP17A1. It is used to treat metastatic, castration-resistant prostate cancer.
Veledimex S enantiomer
Veledimex S enantiomer is the S enantiomer of veledimex which is an orally active small molecule diacylhydrazine and controls the expression of the target gene.
Naloxegol is a CYP3A4 enzyme inhibitor. It is also a peripherally-selective opioid antagonist. It is used as the treatment of opioid-induced constipation. lt is...
TMS is a selective, competitive inhibitor of cytochrome P450 1B1 which has a very high degree of selectivity for P450 1B1 versus both P450 1A1 (>50-fold) and P4...
Anastrozole is an aromatase inhibitor that acts via binding competitively to the hem group of the CYP unit of the enzyme thereby reducing estrogen biosynthesis ...
Dafadine-A, the first identified chemical inhibitor of DAF-9, could restrain the dauer formation, developmental timing and longevity in the nematodeCaenorhabdit...
UK 39671 is a cytochrome P-450 inhibitor
Methoxsalen — also called xanthotoxin, marketed under the trade names Oxsoralen, Deltasoralen, Meladinine — is a drug used to treat psoriasis, eczema, vitiligo,...
CFG920 is a Steroid 17-alpha-hydroxylase inhibitor originated by Novartis. It has potential antiandrogen and antineoplastic activities. It may inhibit cell prol...
Chlorzoxazone is a muscle-relaxing drug, and a probe for human liver cytochrome P-450IIE1.
Naringin inhibits hepatic P-glycoprotein (P-gp) and some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug i...
VT-1161 is a 14-alpha demethylase inhibitor as a tetrazole antifungal agent originated by Viamet Pharmaceuticals. VT-1161 shows potent efficacy in treatment of ...
Proadifen hydrochloride is a Cytochrome P450 inhibitor (IC50 = 19μM) and stimulate endothelial cell prostacyclin production.
BMS-351 is a selective and nonsteroidal CYP17A1 lyase inhibitor with good selectivity over steroidogenic CYPs 21A2 and 11B1. BMS-351 has become a preclinical ca...