|Description||Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity with IC50 value of 36 nM for inhibition of phosphodiesterase 3. It inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. It is antithrombocythemic used for the treatment of overproduction of blood platelets. It is a synthetic quinazoline derivative and is used as is a platelet-reducing agent. It reduces platelet production through a decrease in megakaryocyte maturation. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. It is a drug used for the treatment of essential thrombocytosis or overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia. It was developed by Shire and has been listed.|
|Synonyms||6,7-Dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one;6-Chloro-1,2,3,5-tetrahydro iMidazo [2,1-b]quinazolin-2-one;Agrelin;Agrylin;Xagrid;Shire;Thromboreductin|
|Solubility||Soluble in DMSO, not in water|
|Application||Anagrelide is used for the treatment of overproduction of blood platelets. It is a drug used for the treatment of essential thrombocytosis or overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia.|
|Quality Standard||In-house standard|
|Quantity||Kilograms to Tons|
|Boiling Point||376.5°C at 760 mmHg|
|Melting Point||280 °C|
|Density||1.77±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||Anagrelide was developed by Shire and has been listed.|
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