|Description||(+)-Anabasine hydrochloride is a nicotine alkaloid present in tobacco products. It is a high affinity neuronal nicotinic ACh receptor partial agonist with Ki values of 0.058, 0.26 and 7.2 μM for rat α7, rat α4β2 and fish skeletal muscle nAChRs respectively. It also stimulates Ca2+-dependent catecholamine release from rat adrenomedullary cells in vitro. It is used as an indicator of smoking or tobacco use.|
|Purity||≥99% by HPLC|
Pentolonium tartrate is the tartrate salt form of pentolinium, which is a ganglionic blocking agent and acts as a nicotinic acetylcholine receptor antagonist. I...
Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine。
1-Acetyl-4-methylpiperazine hydrochloride is the hydrochloride salt of 1-Acetyl-4-methylpiperazine which is a structural analog of acetylcholine. It acts as a n...
α-Conotoxin AuIB is a selective antagonist of α3β4 nicotinic acetylcholine receptors. It shows > 100-fold selectivity over other receptor subunit combinations.
Sofinicline is a novel nicotinic acetylcholine receptor agonist under development of Abbott Laboratories. Till now, no development was reported for Phase-II for...
PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
α-Conotoxin PIA is a nicotinic acetylcholine receptor antagonist. It is selective for α6-containing nicotinic receptors. It can discriminate between the closely...
TC 2559 difumarate
TC 2559 difumarate is a subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC50 = 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2...