α-Amyrin palmitate - CAS 22255-10-3
Catalog number: 22255-10-3
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C46H80O2
Molecular Weight:
665.1
COA:
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Chemical Family:
Triterpenoids
Description:
Alpha-Amyrin palmitate is a natural triterpenoid found in the herbs of Ficus tikoua, it is antiarthritic in the adjuvant model of arthritis in rats. Alpha-Amyrin palmitate returns the increases in serum hyaluronate and blood granulocytes toward non-arthritic levels and corrected the moderate anaemia of adjuvant arthritis.
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Purity:
>95%
Appearance:
Solid
Synonyms:
(3S,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-4,4,6a,6b,8a,11,12,14b-octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl palmitate
MSDS:
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Application:
antiarthritic
Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
1.Bioactive triterpenes from Diospyros blancoi.
Ragasa CY;Puno MR;Sengson JM;Shen CC;Rideout JA;Raga DD Nat Prod Res. 2009;23(13):1252-8. doi: 10.1080/14786410902951054.
The ethyl acetate extract of the air-dried leaves of Diospyros blancoi afforded isoarborinol methyl ether (1), a mixture of alpha-amyrin palmitate, alpha-amyrin palmitoleate, beta-amyrin palmitate and beta-amyrin palmitoleate (2) in a 13 : 4 : 3 : 1 ratio, and squalene. The structures of 1, 2 and squalene were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1 and 2 exhibited antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Staphylococcus aureus and Trichophyton mentagrophytes, and were found inactive against Bacillus subtilis and Aspergillus niger. Sample 2 exhibited significant analgaesic and anti-inflammatory activities.
2.Inhibition of serine proteases by anti-inflammatory triterpenoids.
Rajic A;Kweifio-Okai G;Macrides T;Sandeman RM;Chandler DS;Polya GM Planta Med. 2000 Apr;66(3):206-10.
The lupane triterpenoid lupeol, the ursane triterpenoid alpha-amyrin and esters of these compounds are present in the bark of roots of Alstonia boonei (Apocynaceae) and have anti-inflammatory properties. alpha-Amyrin is a competitive inhibitor of bovine trypsin and chymotrypsin (Ki values 29 microM and 18 microM, respectively). Lupeol linoleate, lupeol palmitate and alpha-amyrin linoleate are non-competitive inhibitors of trypsin (Ki values 7 microM, 10 microM and 16 microM, respectively). alpha-Amyrin linoleate is also a non-competitive inhibitor of chymotrypsin (Ki value 28 microM). Lupeol is a competitive inhibitor of both trypsin and chymotrypsin (Ki values 22 and 8 microM, respectively). alpha-Amyrin palmitate is a potent non-competitive inhibitor of chymotrypsin (Ki 6 microM). Lupeol, alpha-amyrin and the palmitic and linoleic acid esters of these compounds are ineffective or very weak as inhibitors of porcine pancreatic elastase and of Lucilia cuprina and Helicoverpa punctigera leucine aminopeptidases. These hydrophobic triterpenoids represent further examples of anti-inflammatory triterpenoids that are PKA inhibitors as well as being selective protease inhibitors.
3.Two new triterpene esters from the twigs of Brachylaena ramiflora from the Madagascar rainforest.
Chaturvedula VS;Schilling JK;Miller JS;Andriantsiferana R;Rasamison VE;Kingston DG J Nat Prod. 2002 Aug;65(8):1222-4.
Bioassay-guided fractionation of a CH(2)Cl(2)/MeOH extract of the small twigs of Brachylaena ramiflora var. ramiflora resulted in the isolation of the two new triterpene esters 1 and 2 and five known triterpenoids, alpha-amyrin palmitate (3), beta-amyrin palmitate (4), beta-amyrin acetate (5), lupeyl acetate (6), and lupeol (7). The structures of the two new compounds were established as kairatenyl palmitate (1) and hopenyl palmitate (2) on the basis of 1D and 2D NMR spectroscopic data interpretation and chemical conversions. All the isolated compounds showed weak cytotoxicity against the A2780 human ovarian cancer cell line.
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CAS 22255-10-3 α-Amyrin palmitate

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