Amylin (rat) - CAS 124447-81-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C167H272N52O53S2
Molecular Weight:
3920.43
COA:
Inquire
Targets:
CGRP Receptor
Description:
Amylin (rat), islet Amyloid Polypeptide (IAPP), is a glucoregulatory peptide from rat pancreatic cells. It inhibits glucagon secretion, delays gastric emptying and acts as a satiety agent. It is used to study the regulation of satiety and obesity. It binds to heteromeric complexes of human calcitonin receptor 2 (CTR2) with receptor activity-modifying protein (RAMP) 1 or 3. It also binds to mouse α-thyroid-stimulating hormone thyrotroph (α-TSH) cells and rat nucleus accumbens membrane preparations. It inhibits insulin-induced, but not basal, glycogen synthesis in hepatocytes isolated from fasted rats in vitro. It does not form fibrils and is not cytotoxic unlike human amylin. It is active in vivo.
Synonyms:
L-​lysyl-​L-​cysteinyl-​L-​asparaginyl-​L-​threonyl-​L-​alanyl-​L-​threonyl-​L-​cysteinyl-​L-​alanyl-​L-​threonyl-​L-​glutaminyl-​L-​arginyl-​L-​leucyl-​L-​alanyl-​L-​asparaginyl-​L-​phenylalanyl-​L-​leucyl-​L-​valyl-​L-​arginyl-​L-​seryl-​L-​seryl-​L-​asparaginyl-​L-​asparaginyl-​L-​leucylglycyl-​L-​prolyl-​L-​valyl-​L-​leucyl-​L-​prolyl-​L-​prolyl-​L-​threonyl-​L-​asparaginyl-​L-​valylglycyl-​L-​seryl-​L-​asparaginyl-​L-​threonyl-​, cyclic (2→7)​-​disulfide L-​tyrosinamide; Rat amylin; Rat amylin amide; Rat islet amyloid polypeptide
MSDS:
Inquire
InChIKey:
AGQDOUOEJSDDQH-BJQYWQRQSA-N
InChI:
InChI=1S/C167H272N52O53S2/c1-72(2)53-95(136(243)185-66-122(237)217-50-30-38-111(217)154(261)211-125(78(13)14)158(265)204-105(56-75(7)8)164(271)219-52-32-40-113(219)165(272)218-51-31-39-112(218)155(262)216-130(86(22)227)162(269)203-104(64-120(176)235)146(253)209-123(76(9)10)156(263)184-65-121(236)189-106(67-220)149(256)201-102(62-118(174)233)147(254)215-129(85(21)226)161(268)193-94(131(177)238)57-88-41-43-89(228)44-42-88)195-143(250)100(60-116(172)231)199-144(251)101(61-117(173)232)200-150(257)107(68-221)206-151(258)108(69-222)205-138(245)92(37-29-49-183-167(180)181)191-157(264)124(77(11)12)210-145(252)97(55-74(5)6)197-141(248)98(58-87-33-24-23-25-34-87)198-142(249)99(59-115(171)230)194-132(239)79(15)186-140(247)96(54-73(3)4)196-137(244)91(36-28-48-182-166(178)179)190-139(246)93(45-46-114(170)229)192-160(267)127(83(19)224)212-133(240)80(16)187-152(259)109-70-273-274-71-110(207-135(242)90(169)35-26-27-47-168)153(260)202-103(63-119(175)234)148(255)214-126(82(18)223)159(266)188-81(17)134(241)213-128(84(20)225)163(270)208-109/h23-25,33-34,41-44,72-86,90-113,123-130,220-228H,26-32,35-40,45-71,168-169H2,1-22H3,(H2,170,229)(H2,171,230)(H2,172,231)(H2,173,232)(H2,174,233)(H2,175,234)(H2,176,235)(H2,177,238)(H,184,263)(H,185,243)(H,186,247)(H,187,259)(H,188,266)(H,189,236)(H,190,246)(H,191,264)(H,192,267)(H,193,268)(H,194,239)(H,195,250)(H,196,244)(H,197,248)(H,198,249)(H,199,251)(H,200,257)(H,201,256)(H,202,260)(H,203,269)(H,204,265)(H,205,245)(H,206,258)(H,207,242)(H,208,270)(H,209,253)(H,210,252)(H,211,261)(H,212,240)(H,213,241)(H,214,255)(H,215,254)(H,216,262)(H4,178,179,182)(H4,180,181,183)/t79-,80-,81-,82+,83+,84+,85+,86+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,123-,124-,125-,126-,127-,128-,129-,130-/m0/s1
Canonical SMILES:
CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)C(C)O)CC(=O)N)NC(=O)C(CCCCN)N)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CC(=O)N)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NCC(=O)N3CCCC3C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)N)C(C)O
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related CGRP Receptor Products


CAS 204697-65-4 Olcegepant

Olcegepant
(CAS: 204697-65-4)

Olcegepant, also called as BIBN4096BS or BIBN 4096, is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) re...

CAS 124447-81-0 Amylin (rat)

Amylin (rat)
(CAS: 124447-81-0)

Amylin (rat), islet Amyloid Polypeptide (IAPP), is a glucoregulatory peptide from rat pancreatic cells. It inhibits glucagon secretion, delays gastric emptying ...

Rimegepant
(CAS: 1289023-67-1)

Rimegepant, a CGRP receptor antagonist, has been found to have potential effect against Migraine by Bristol-Myers Squibb. The Phase II trial of it has already b...

Ubrogepant
(CAS: 1374248-77-7)

Ubrogepant is and selective oral calcitonin gene-related peptide (CGRP) receptor antagonist originated by Merck & Co. In Sep 2016, Allergan initiated a phase II...

CAS 586368-06-1 Olcegepant hydrochloride

Olcegepant hydrochloride
(CAS: 586368-06-1)

Olcegepant hydrochloride is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with 150-fold select...

BMS694153
(CAS: 1050381-35-5)

BMS694153 is a potent and selective calcitonin gene-related peptide(CGRP) receptor antagonist. It is related with the pathogenesis of migraine.

CAS 957116-20-0 MK-3207 HCl

MK-3207 HCl
(CAS: 957116-20-0)

MK-3207 is a potent CGRP receptor antagonist with IC50 and Ki of 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3.

CAS 129121-73-9 CGRP 8-37 (rat)

CGRP 8-37 (rat)
(CAS: 129121-73-9)

CGRP 8-37 (rat) is a peptide antagonist for CGRP1 receptors.

Chemical Structure

CAS 124447-81-0 Amylin (rat)

Quick Inquiry

Verification code

Featured Items