Amprolium HCl - CAS 137-88-2
Catalog number: 137-88-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C14H19N4.HCl.Cl
Molecular Weight:
315.24
COA:
Inquire
Targets:
Antiparasitic
Description:
Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake.
Purity:
>98%
MSDS:
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InChIKey:
PJBQYZZKGNOKNJ-UHFFFAOYSA-M
InChI:
InChI=1S/C14H19N4.2ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1
Canonical SMILES:
CCCC1=NC=C(C(=N1)N)C[N+]2=CC=CC=C2C.Cl.[Cl-]
1.Kinetic behaviour of sulphaquinoxaline and amprolium in chickens.
el-Sayed MG1, Abd el-Aziz MI, el-Kholy MH. Dtsch Tierarztl Wochenschr. 1995 Dec;102(12):481-5.
The pharmacokinetics of sulphaquinoxaline and amprolium hydrochloride were studied in Hubbard broiler chickens. Single doses of sulphaquinoxaline (100 mg/kg b. wt.), and amprolium hydrochloride (30 mg/kg b. wt.) were administered orally and intravenously to the same birds with 15 days interval between treatments. Sulphaquinoxaline and amprolium HCl were determined colorimetrically. Following i.v. administration, the concentration-time curve of sulphaquinoxaline and amprolium could be explained by a two compartments open model with a t1/2 alpha of 0.16 +/- 0.008 h; 0.17 +/- 0.09 h; t1/2 beta of 12.6 +/- 0.32 h, 4.89 +/- 0.3 h respectively. The total body clearance were 0.278 +/- 0.013 ml/kg/min; 0.562 +/- 0.015 ml/kg/min; volume of distribution at steady state were 0.44 +/- 0.009 L/kg, 0.34 +/- 0.005 L/kg and systemic bioavailability following oral administration were 72.65 +/- 3.38, 66.09 +/- 4.9 percent for sulphaquinoxaline and amprolium HCl respectively.
2.Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae).
Molnár K1, Ostoros G. Acta Vet Hung. 2007 Mar;55(1):67-76.
In this study, nine anticoccidial drugs commonly used in poultry were tested for efficacy for the prevention and treatment of Goussia carpelli (Apicomplexa) infection in common carp (Cyprinus carpio L.). To establish experimental infection with G. carpelli, paratenic host oligochaetes of the genera Tubifex and Limnodrilus were infected with oocysts, and laboratory-cultured parasite-free common carp fingerlings were infected by feeding to them oligochaetes containing sporozoites. The anticoccidial drugs (amprolium, narasin, maduramicin, salinomycin Na, lasalocid Na, diclazuril, robenidine HCl, monensin Na and toltrazuril), mixed in the food of the fish in a dose of 200 mg/kg, were fed for 12 days. Common carp fingerlings fed diclazuril, lasalocid, robenidine HCl or maduramicin and killed on day 14 after exposure were free from infection, while other groups treated with amprolium, toltrazuril, monensin Na, narasin or salinomycin Na harboured oocysts in the mucus and epithelium of the gut.
3.Control of Isospora suis-induced coccidiosis on a swine farm.
Ernst JV, Lindsay DS, Current WL. Am J Vet Res. 1985 Mar;46(3):643-5.
Results of a program designed to control neonatal porcine coccidiosis on a total confinement, farrow-to-finish swine farm are reported. The control program consisted of washing, phenol disinfection, and steam cleaning of farrowing houses and treatment of sows with amprolium HCl before and after farrowing. Before initiation of the control program, 88.9% of the sows examined in the farrowing house were negative for coccidian oocysts, 9.9% were positive for Eimeria spp, and 1.2% were positive for Isospora suis. Most pigs nursing on sows before initiation of the control program had diarrhea at 5 to 10 days of age, which led to dehydration and weight loss. Morbidity was high, and mortality was moderate. Composite fecal samples from these litters were all positive (100%) for I suis. After initiation of the control program, 99.6% of the sows examined in the farrowing house were negative for coccidian oocysts and 0.4% were positive for Eimeria spp.
4.Inhibition of thiamine transport across the blood-brain barrier in the rat by a chemical analogue of the vitamin.
Greenwood J, Pratt OE. J Physiol. 1983 Mar;336:479-86.
The flux of thiamine from the blood into the brain has been measured using a specially devised technique by which a steady raised level of the vitamin, with or without radioactive labelling, can be achieved rapidly and maintained in the bloodstream. This is done by a continuous injection, given at a rate which is adjusted by a pre-determined programme so as to replace the tracer at the rate at which it has been found to leave the circulation in previous experiments. A further programme was worked out to maintain, in a similar manner by a separate injection, a steady raised level in the bloodstream of a chemical analogue of thiamine, 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-picolinium chloride HCl (amprolium). In the presence of a high concentration of amprolium the flux of thiamine across the blood-brain barrier was greatly reduced and no longer saturable by raising the blood thiamine concentration up to at least 10 microM. It was concluded that this analogue of thiamine inhibited the saturable component of thiamine transport across the barrier but not the non-saturable component.
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CAS 137-88-2 Amprolium HCl

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