Amprolium HCl - CAS 137-88-2
Catalog number: 137-88-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake.
Publictions citing BOC Sciences Products
  • >> More
1.Kinetic behaviour of sulphaquinoxaline and amprolium in chickens.
el-Sayed MG1, Abd el-Aziz MI, el-Kholy MH. Dtsch Tierarztl Wochenschr. 1995 Dec;102(12):481-5.
The pharmacokinetics of sulphaquinoxaline and amprolium hydrochloride were studied in Hubbard broiler chickens. Single doses of sulphaquinoxaline (100 mg/kg b. wt.), and amprolium hydrochloride (30 mg/kg b. wt.) were administered orally and intravenously to the same birds with 15 days interval between treatments. Sulphaquinoxaline and amprolium HCl were determined colorimetrically. Following i.v. administration, the concentration-time curve of sulphaquinoxaline and amprolium could be explained by a two compartments open model with a t1/2 alpha of 0.16 +/- 0.008 h; 0.17 +/- 0.09 h; t1/2 beta of 12.6 +/- 0.32 h, 4.89 +/- 0.3 h respectively. The total body clearance were 0.278 +/- 0.013 ml/kg/min; 0.562 +/- 0.015 ml/kg/min; volume of distribution at steady state were 0.44 +/- 0.009 L/kg, 0.34 +/- 0.005 L/kg and systemic bioavailability following oral administration were 72.65 +/- 3.38, 66.09 +/- 4.9 percent for sulphaquinoxaline and amprolium HCl respectively.
2.Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae).
Molnár K1, Ostoros G. Acta Vet Hung. 2007 Mar;55(1):67-76.
In this study, nine anticoccidial drugs commonly used in poultry were tested for efficacy for the prevention and treatment of Goussia carpelli (Apicomplexa) infection in common carp (Cyprinus carpio L.). To establish experimental infection with G. carpelli, paratenic host oligochaetes of the genera Tubifex and Limnodrilus were infected with oocysts, and laboratory-cultured parasite-free common carp fingerlings were infected by feeding to them oligochaetes containing sporozoites. The anticoccidial drugs (amprolium, narasin, maduramicin, salinomycin Na, lasalocid Na, diclazuril, robenidine HCl, monensin Na and toltrazuril), mixed in the food of the fish in a dose of 200 mg/kg, were fed for 12 days. Common carp fingerlings fed diclazuril, lasalocid, robenidine HCl or maduramicin and killed on day 14 after exposure were free from infection, while other groups treated with amprolium, toltrazuril, monensin Na, narasin or salinomycin Na harboured oocysts in the mucus and epithelium of the gut.
3.Control of Isospora suis-induced coccidiosis on a swine farm.
Ernst JV, Lindsay DS, Current WL. Am J Vet Res. 1985 Mar;46(3):643-5.
Results of a program designed to control neonatal porcine coccidiosis on a total confinement, farrow-to-finish swine farm are reported. The control program consisted of washing, phenol disinfection, and steam cleaning of farrowing houses and treatment of sows with amprolium HCl before and after farrowing. Before initiation of the control program, 88.9% of the sows examined in the farrowing house were negative for coccidian oocysts, 9.9% were positive for Eimeria spp, and 1.2% were positive for Isospora suis. Most pigs nursing on sows before initiation of the control program had diarrhea at 5 to 10 days of age, which led to dehydration and weight loss. Morbidity was high, and mortality was moderate. Composite fecal samples from these litters were all positive (100%) for I suis. After initiation of the control program, 99.6% of the sows examined in the farrowing house were negative for coccidian oocysts and 0.4% were positive for Eimeria spp.
4.Inhibition of thiamine transport across the blood-brain barrier in the rat by a chemical analogue of the vitamin.
Greenwood J, Pratt OE. J Physiol. 1983 Mar;336:479-86.
The flux of thiamine from the blood into the brain has been measured using a specially devised technique by which a steady raised level of the vitamin, with or without radioactive labelling, can be achieved rapidly and maintained in the bloodstream. This is done by a continuous injection, given at a rate which is adjusted by a pre-determined programme so as to replace the tracer at the rate at which it has been found to leave the circulation in previous experiments. A further programme was worked out to maintain, in a similar manner by a separate injection, a steady raised level in the bloodstream of a chemical analogue of thiamine, 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-picolinium chloride HCl (amprolium). In the presence of a high concentration of amprolium the flux of thiamine across the blood-brain barrier was greatly reduced and no longer saturable by raising the blood thiamine concentration up to at least 10 microM. It was concluded that this analogue of thiamine inhibited the saturable component of thiamine transport across the barrier but not the non-saturable component.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antiparasitic Products

CAS 102-65-8 Sulfaclozine

(CAS: 102-65-8)

Sulfaclozine, a sulfonamide derivative, is a potent antibacterial and anticoccidial agent which is commonly used as a veterinary drug.

CAS 117704-25-3 Doramectin

(CAS: 117704-25-3)

Doramectin is an antiparasitic agent.

CAS 7681-76-7 Ronidazole

(CAS: 7681-76-7)

Ronidazole is an antiprotozoal agent.

CAS 121-25-5 Amprolium

(CAS: 121-25-5)

Amprolium, a thiamine derivative, could be commonly useful in poultry as a coccidiostat.

CAS 14852-14-3 Piperazine malate

Piperazine malate
(CAS: 14852-14-3)

An anthelmintic

CAS 1310455-86-7 GNF179 Metabolite

GNF179 Metabolite
(CAS: 1310455-86-7)

GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=...

CAS 51-03-6 Piperonyl butoxide

Piperonyl butoxide
(CAS: 51-03-6)

Piperonyl butoxide works as an insecticide synergist. It is useful in inhibitng the insect microsomal enzyme detoxification activity and is always under the com...

CAS 134-62-3 N,N-Diethyl-3-methylbenzamide

(CAS: 134-62-3)

N,N-Diethyl-3-methylbenzamide, a benzamide derivative, could be a significant additive in vermifuge.

CAS 100-33-4 Pentamidine

(CAS: 100-33-4)

Pentamidine is an antimicrobial agent.

CAS 95233-18-4 Atovaquone

(CAS: 95233-18-4)

Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.

CAS 65195-55-3 Avermectin B1a

Avermectin B1a
(CAS: 65195-55-3)

Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis. It is a macrocyclic lactone that makes ...

CAS 60200-06-8 Clorsulon

(CAS: 60200-06-8)

Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.

CAS 1010411-21-8 GSK369796 Dihydrochloride

GSK369796 Dihydrochloride
(CAS: 1010411-21-8)

SK369796, also known as N-tert-butylisoquine, shows antimalerial activity with IC50 values of 11.2 nM for 3D7 strain, 12.6 nM for HB3 strain, 17.6 nM for K1 str...

CAS 521-74-4 Broxyquinoline

(CAS: 521-74-4)

Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.

CAS 52645-53-1 Permethrin

(CAS: 52645-53-1)

Permethrin is a synthetic pyrethroid insectide, affecting neuron membranes by prolonging sodium channel activation.

CAS 1263-89-4 Paromomycin Sulfate

Paromomycin Sulfate
(CAS: 1263-89-4)

Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.

(CAS: 864731-61-3)

Fluralaner is a systemic insecticide and acaricide. It can be used for flea treatment in dogs.

CAS 88426-33-9 Buparvaquone

(CAS: 88426-33-9)

Buparvaquone is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone. It is a promising compound for the therapy and prophylaxis of a...

CAS 6506-37-2 Nimorazole

(CAS: 6506-37-2)

Nimorazole is a nitroimidazole anti-infective. It significantly improves the effect of radiotherapeutic management of supraglottic and pharynx tumors and can be...

CAS 40596-69-8 Methoprene

(CAS: 40596-69-8)

Methoprene, is a juvenile hormone (JH) analog which can be used as an a biological pesticide.

Chemical Structure

CAS 137-88-2 Amprolium HCl

Quick Inquiry

Verification code

Featured Items